Mitomycin-C in Post-endoscopic Septoplasty Synechiae: Does it Really Helps?

Endoscopic septoplasty has advantage of magnified image and access to posterior part of the septum. Synechiae formation is a common complication of this procedure. The incidence of adhesions rises particularly in cases of submucosal flap tears which is sometimes unavoidable during spurectomy. Variou...

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Published in:Indian journal of otolaryngology, and head, and neck surgery and head, and neck surgery, 2019-11, Vol.71 (Suppl 3), p.2091-2095
Main Authors: Sayeed, Abu, Alam, Mehtab, Sharma, Satish Chandra, Hasan, Syed Abrar
Format: Article
Language:English
Subjects:
Endoscopy
Head and Neck Surgery
Maxillofacial surgery
Medicine
Medicine & Public Health
Nose
Original
Original Article
Otolaryngology
Otorhinolaryngology
Sinuses
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Summary:Endoscopic septoplasty has advantage of magnified image and access to posterior part of the septum. Synechiae formation is a common complication of this procedure. The incidence of adhesions rises particularly in cases of submucosal flap tears which is sometimes unavoidable during spurectomy. Various procedures like septal splints, nasal packings have been tried to reduce the incidence of adhesions. Recently mitomycin-C is being tried to decrease post operative adhesions after Functional Endoscopic Sinus Surgery, endoscopic Dacrocystorhinostomy, with varying degree of success. Mitomycin-C has got anti fibroblastic activity, which inhibits the fibroblasts without hampering epithelization. Eighty (80) Patients undergoing septoplasty and spurectomy were observed for any submucosal flap tear, and those developing flap tear were included in the study. The patients were divided into 2 groups of 40 each. In group-1 topical mitomycin (0.4 mg/ml) was applied at the raw area for 5 min, similarly normal saline was applied in group-2 (control).The aim of study was to evaluate the role of mitomycin-C in preventing post operative adhesions in Endoscopic septoplasty. Adhesion rate was calculated at 1 month, and compared using Chi square test. P value 
ISSN:2231-3796
0973-7707
DOI:10.1007/s12070-018-1496-z