Optimizing ablation duration using dormant conduction to reveal incomplete isolation with the second generation cryoballoon: A randomized controlled trial

Introduction Efficacy of cryoballoon ablation depends on balloon‐tissue contact and ablation duration. Prolonged duration may increase extracardiac complications. The aim of this study is to determine the optimal additional ablation duration after acute pulmonary vein isolation (PVI). Methods Consec...

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Bibliographic Details
Published in:Journal of cardiovascular electrophysiology 2019-06, Vol.30 (6), p.902-909
Main Authors: Keçe, Fehmi, Riva, Marta, Naruse, Yoshihisa, Alizadeh Dehnavi, Reza, Wijnmaalen, Adrianus P., Schalij, Martin J., Zeppenfeld, Katja, Trines, Serge A.
Format: Article
Language:English
Subjects:
Ablation
Action Potentials
Aged
atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Cardiac Catheters
Complications
Conduction
cryoballoon ablation
Cryosurgery - adverse effects
Cryosurgery - instrumentation
dormant conduction
Equipment Design
Esophagus
Female
Fibrillation
Heart Rate
Humans
Male
Middle Aged
Netherlands
Operative Time
Original
Phrenic nerve
Prospective Studies
pulmonary vein isolation
Pulmonary Veins - physiopathology
Pulmonary Veins - surgery
Randomization
Recurrence
Risk Assessment
Risk Factors
Temperature
Time Factors
time‐to‐isolation
Treatment Outcome
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Summary:Introduction Efficacy of cryoballoon ablation depends on balloon‐tissue contact and ablation duration. Prolonged duration may increase extracardiac complications. The aim of this study is to determine the optimal additional ablation duration after acute pulmonary vein isolation (PVI). Methods Consecutive patients with paroxysmal AF were randomized to three groups according to additional ablation duration (90, 120, or 150 seconds) after acute PVI (time‐to‐isolation). Primary outcome was reconnection/dormant conduction (DC) after a 30 minutes waiting period. If present, additional 240 seconds ablations were performed. Ablations without time‐to‐isolation
ISSN:1045-3873
1540-8167
DOI:10.1111/jce.13913