Growth‐associated protein 43 promotes thyroid cancer cell lines progression via epithelial‐mesenchymal transition

Thyroid cancer is maintaining at a high incidence level and its carcinogenesis is mainly affected by a complex gene interaction. By analysis of the next‐generation resequencing of paired papillary thyroid cancer (PTC) and adjacent thyroid tissues, we found that Growth Associated Protein 43 (GAP43),...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2019-12, Vol.23 (12), p.7974-7984
Main Authors: Zheng, Chen, Quan, Rui‐Da, Wu, Cheng‐Yong, Hu, Jing, Lin, Bang‐Yi, Dong, Xu‐Bing, Xia, Er‐Jie, Bhandari, Adheesh, Zhang, Xiao‐Hua, Wang, Ou‐Chen
Format: Article
Language:English
Subjects:
Adult
Apoptosis
Apoptosis - genetics
Carcinogenesis
Cell growth
Cell Line, Tumor
Cell migration
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Cohort Studies
Databases, Genetic
EMT
Epithelial-Mesenchymal Transition - genetics
Female
GAP-43 Protein - genetics
GAP-43 Protein - metabolism
GAP43
Gene Expression Regulation, Neoplastic - genetics
Gene Knockdown Techniques
Genomes
High-Throughput Nucleotide Sequencing
Humans
Kinases
lymph node metastasis
Lymph nodes
Lymphatic Metastasis
Male
Mesenchyme
Metastases
Middle Aged
Mutation
Neoplasm Invasiveness - genetics
Neoplasm Staging
oncogene
Original
Papillary thyroid cancer
Protein kinase C
Risk Factors
RNA, Small Interfering
Therapeutic applications
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Cancer, Papillary - metabolism
Thyroid Cancer, Papillary - pathology
Thyroid carcinoma
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyroid Neoplasms - secondary
Tumor cell lines
Tumors
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Summary:Thyroid cancer is maintaining at a high incidence level and its carcinogenesis is mainly affected by a complex gene interaction. By analysis of the next‐generation resequencing of paired papillary thyroid cancer (PTC) and adjacent thyroid tissues, we found that Growth Associated Protein 43 (GAP43), a phosphoprotein activated by protein kinase C, might be novel markers associated with PTC. However, its function in thyroid carcinoma has been poorly understood. We discovered that GAP43 was significantly overexpressed in thyroid carcinoma and these results were consistent with that in The Cancer Genome Atlas (TCGA) cohort. In addition, some clinicopathological features of GAP43 in TCGA database showed that up‐regulated GAP43 is significantly connected to lymph node metastasis (P 
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.14460