Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are pr...

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Bibliographic Details
Published in:Interdisciplinary toxicology 2018-10, Vol.11 (3), p.217-220
Main Authors: Stara, Veronika, Mach, Mojmir, Ujhazy, Eduard, Liptak, Boris, Gasparova, Zdenka
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal memory
Cognitive ability
Dementia
Dementia disorders
Handling
Latency
Memory
Memory tasks
Neonates
Neurodegeneration
Neurodegenerative diseases
Original
Rodents
Spatial analysis
Spatial memory
Trimethyltin
Young adults
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Summary:Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer's disease and dementia.
ISSN:1337-9569
1337-6853
1337-9569
DOI:10.2478/intox-2018-0020