The Effect of High-concentration Insulin Glarigine on the Quality of Life of Patients with Type 2 Diabetes Mellitus: A Pre-post Study (HIGH-QOL STUDY)

• Published in: Internal Medicine 2019/10/15, Vol.58(20), pp.2943-2948
• Main Authors: Murata, Takashi, Tone, Atsuhito, Kouyama, Ryuji, Kamiuchi, Kenji, Narasaki, Kohshi, Tsuruo, Miho, Watanabe, Tomokazu, Kawashima, Satoshi, Kato, Ken, Sawaki, Hideaki, Osawa, Kensou, Kimura, Moritsugu, Toyoda, Masao, Suganuma, Akiko, Sakane, Naoki, on behalf of HIGH-QOL study group
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; concentration; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Drug Administration Schedule; Drug Compounding; Female; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Injection; Injections, Subcutaneous - adverse effects; Insulin; insulin glargine; Insulin Glargine - administration & dosage; Insulin Glargine - adverse effects; Internal medicine; Male; Middle Aged; Original; Pain; Pain - etiology; Pain Measurement - methods; Patient Preference; Psychometrics; Quality of Life; type 2 diabetes mellitus
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.1794-18

Objective We compared the pain accompanying the injection of high-concentration (300 units/mL) insulin glargine (U300G) with that accompanying the injection of conventional (100 units/mL) insulin glargine (U100G). Methods U100G was switched to U300G at basically the same dosage. Visual analog scales were used to assess the quality of life (QOL). The primary outcome was the change in the pain accompanying injections in those using ≥30 units of U100G compared with those using