Decrease in Butyrylcholinesterase Accompanied by Intermediate-like Syndrome after Massive Ingestion of a Glyphosate-surfactant

An 86-year-old woman intentionally drank approximately 300 mL of a glyphosate-surfactant. She was found with consciousness disturbance and experienced several vomiting episodes. On arrival, serum biochemistry revealed a decreased level of butyrylcholinesterase (B-CHE) [11 (normal range: 180-450) IU/...

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Bibliographic Details
Published in:Internal Medicine 2019/10/15, Vol.58(20), pp.3057-3059
Main Authors: Takeuchi, Ikuto, Yanagawa, Youichi, Nagasawa, Hiroki, Jitsuiki, Kei, Madokoro, Shunsuke, Takahashi, Norihito, Ohsaka, Hiromichi, Ishikawa, Kouhei, Omori, Kazuhiko
Format: Article
Language:English
Subjects:
Aged, 80 and over
Biomarkers - blood
butyrylcholinesterase
Butyrylcholinesterase - blood
Case Report
Coma
Coma - blood
Coma - chemically induced
Consciousness
Eating
Female
Glycine - analogs & derivatives
Glycine - poisoning
Glyphosate
glyphosate-surfactant
Humans
Ingestion
intermediate syndrome
Internal medicine
Muscles
Surface-Active Agents - adverse effects
Surfactants
Syndrome
Vomiting
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Summary:An 86-year-old woman intentionally drank approximately 300 mL of a glyphosate-surfactant. She was found with consciousness disturbance and experienced several vomiting episodes. On arrival, serum biochemistry revealed a decreased level of butyrylcholinesterase (B-CHE) [11 (normal range: 180-450) IU/L]. Later, her B-CHE level further decreased to single-digit values, and she became comatose with involuntary movement and an increase in muscle tone. Her consciousness level and muscle tone improved with the recovery of her B-CHE level. Physicians should be alert for the occurrence of intermediate syndrome when the B-CHE levels of patients who have consumed a massive amount of glyphosate-surfactant show a prolonged decrease.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2562-18