Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis

• Published in: Maternal and child nutrition 2013-07, Vol.9 (3), p.285-298
• Main Authors: Nissensohn, Mariela, Sánchez Villegas, Almudena, Fuentes Lugo, Daniel, Henríquez Sánchez, Patricia, Doreste Alonso, Jorge, Lowe, Nicola M., Hall Moran, Victoria, Skinner, Anna Louise, Warthon Medina, Marisol, Serra-Majem, Lluis
• Format: Article
• Language: English
• Subjects: Databases, Factual; Dietary Supplements; Europe; EURRECA; Humans; Infant; infants; Nutritional Status; Randomized Controlled Trials as Topic; Review; serum/plasma Zn status; Zinc - administration & dosage; Zinc - blood; Zinc - pharmacokinetics; zinc intake
• ISSN: 1740-8695; 1740-8709; 1740-8709
• DOI: 10.1111/mcn.12045

A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta‐analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta‐regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054;