Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis

A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying t...

Full description

Saved in:
Bibliographic Details
Published in:Maternal and child nutrition 2013-07, Vol.9 (3), p.285-298
Main Authors: Nissensohn, Mariela, Sánchez Villegas, Almudena, Fuentes Lugo, Daniel, Henríquez Sánchez, Patricia, Doreste Alonso, Jorge, Lowe, Nicola M., Hall Moran, Victoria, Skinner, Anna Louise, Warthon Medina, Marisol, Serra-Majem, Lluis
Format: Article
Language:English
Subjects:
Databases, Factual
Dietary Supplements
Europe
EURRECA
Humans
Infant
infants
Nutritional Status
Randomized Controlled Trials as Topic
Review
serum/plasma Zn status
Zinc - administration & dosage
Zinc - blood
Zinc - pharmacokinetics
zinc intake
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53
cites cdi_FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53
container_end_page 298
container_issue 3
container_start_page 285
container_title Maternal and child nutrition
container_volume 9
creator Nissensohn, Mariela
Sánchez Villegas, Almudena
Fuentes Lugo, Daniel
Henríquez Sánchez, Patricia
Doreste Alonso, Jorge
Lowe, Nicola M.
Hall Moran, Victoria
Skinner, Anna Louise
Warthon Medina, Marisol
Serra-Majem, Lluis
description A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta‐analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta‐regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054;
doi_str_mv 10.1111/mcn.12045
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6860590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1366578935</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53</originalsourceid><addsrcrecordid>eNp1kE9v1DAQxS0EoqX0wBdAOcIhXTuO_4QDElraBaktEipqb9bEGYNp4iyxAyyfnizpruiho5HG0vvNG-sR8oLREzbVorPhhBW0FI_IIVMlzbWi1ePdW1bigDyL8TulfFtPyUHBZalUIQ7JxalzaFPWu-yPDzbzIcEtZn3IIg5jt1i3EDuYtZggjXFCpnYQUnyTQdZhghwCtJvo43PyxEEb8fhuHpEvZ6dXyw_5-afVx-W789yWgovcYVVa3RRotSsAJZTo6hpriqwG21he1Y0EZNRqjlpIrWpdi4IVZVNNkuBH5O3sux7rDhuLIQ3QmvXgOxg2pgdv7ivBfzNf-59GaklFRSeDV3cGQ_9jxJhM56PFtoWA_RgN41IKpSu-vfV6Ru3Qxzig259h1GzjN1P85l_8E_vy_3_tyV3eE7CYgV--xc3DTuZiebmzzOcNHxP-3m_AcGuk4kqY68uV-axuqqub92dmxf8CeXOgeQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1366578935</pqid></control><display><type>article</type><title>Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis</title><source>PubMed Central</source><creator>Nissensohn, Mariela ; Sánchez Villegas, Almudena ; Fuentes Lugo, Daniel ; Henríquez Sánchez, Patricia ; Doreste Alonso, Jorge ; Lowe, Nicola M. ; Hall Moran, Victoria ; Skinner, Anna Louise ; Warthon Medina, Marisol ; Serra-Majem, Lluis</creator><creatorcontrib>Nissensohn, Mariela ; Sánchez Villegas, Almudena ; Fuentes Lugo, Daniel ; Henríquez Sánchez, Patricia ; Doreste Alonso, Jorge ; Lowe, Nicola M. ; Hall Moran, Victoria ; Skinner, Anna Louise ; Warthon Medina, Marisol ; Serra-Majem, Lluis</creatorcontrib><description>A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta‐analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta‐regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054; &lt;0.001 and &lt;0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4–20 weeks and &gt;20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12 mg day−1. In all cases, the pooled β showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence‐based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.</description><identifier>ISSN: 1740-8695</identifier><identifier>ISSN: 1740-8709</identifier><identifier>EISSN: 1740-8709</identifier><identifier>DOI: 10.1111/mcn.12045</identifier><identifier>PMID: 23647725</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Databases, Factual ; Dietary Supplements ; Europe ; EURRECA ; Humans ; Infant ; infants ; Nutritional Status ; Randomized Controlled Trials as Topic ; Review ; serum/plasma Zn status ; Zinc - administration &amp; dosage ; Zinc - blood ; Zinc - pharmacokinetics ; zinc intake</subject><ispartof>Maternal and child nutrition, 2013-07, Vol.9 (3), p.285-298</ispartof><rights>2013 John Wiley &amp; Sons Ltd</rights><rights>2013 John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53</citedby><cites>FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860590/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860590/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23647725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nissensohn, Mariela</creatorcontrib><creatorcontrib>Sánchez Villegas, Almudena</creatorcontrib><creatorcontrib>Fuentes Lugo, Daniel</creatorcontrib><creatorcontrib>Henríquez Sánchez, Patricia</creatorcontrib><creatorcontrib>Doreste Alonso, Jorge</creatorcontrib><creatorcontrib>Lowe, Nicola M.</creatorcontrib><creatorcontrib>Hall Moran, Victoria</creatorcontrib><creatorcontrib>Skinner, Anna Louise</creatorcontrib><creatorcontrib>Warthon Medina, Marisol</creatorcontrib><creatorcontrib>Serra-Majem, Lluis</creatorcontrib><title>Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis</title><title>Maternal and child nutrition</title><addtitle>Matern Child Nutr</addtitle><description>A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta‐analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta‐regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054; &lt;0.001 and &lt;0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4–20 weeks and &gt;20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12 mg day−1. In all cases, the pooled β showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence‐based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.</description><subject>Databases, Factual</subject><subject>Dietary Supplements</subject><subject>Europe</subject><subject>EURRECA</subject><subject>Humans</subject><subject>Infant</subject><subject>infants</subject><subject>Nutritional Status</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>serum/plasma Zn status</subject><subject>Zinc - administration &amp; dosage</subject><subject>Zinc - blood</subject><subject>Zinc - pharmacokinetics</subject><subject>zinc intake</subject><issn>1740-8695</issn><issn>1740-8709</issn><issn>1740-8709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kE9v1DAQxS0EoqX0wBdAOcIhXTuO_4QDElraBaktEipqb9bEGYNp4iyxAyyfnizpruiho5HG0vvNG-sR8oLREzbVorPhhBW0FI_IIVMlzbWi1ePdW1bigDyL8TulfFtPyUHBZalUIQ7JxalzaFPWu-yPDzbzIcEtZn3IIg5jt1i3EDuYtZggjXFCpnYQUnyTQdZhghwCtJvo43PyxEEb8fhuHpEvZ6dXyw_5-afVx-W789yWgovcYVVa3RRotSsAJZTo6hpriqwG21he1Y0EZNRqjlpIrWpdi4IVZVNNkuBH5O3sux7rDhuLIQ3QmvXgOxg2pgdv7ivBfzNf-59GaklFRSeDV3cGQ_9jxJhM56PFtoWA_RgN41IKpSu-vfV6Ru3Qxzig259h1GzjN1P85l_8E_vy_3_tyV3eE7CYgV--xc3DTuZiebmzzOcNHxP-3m_AcGuk4kqY68uV-axuqqub92dmxf8CeXOgeQ</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Nissensohn, Mariela</creator><creator>Sánchez Villegas, Almudena</creator><creator>Fuentes Lugo, Daniel</creator><creator>Henríquez Sánchez, Patricia</creator><creator>Doreste Alonso, Jorge</creator><creator>Lowe, Nicola M.</creator><creator>Hall Moran, Victoria</creator><creator>Skinner, Anna Louise</creator><creator>Warthon Medina, Marisol</creator><creator>Serra-Majem, Lluis</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201307</creationdate><title>Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis</title><author>Nissensohn, Mariela ; Sánchez Villegas, Almudena ; Fuentes Lugo, Daniel ; Henríquez Sánchez, Patricia ; Doreste Alonso, Jorge ; Lowe, Nicola M. ; Hall Moran, Victoria ; Skinner, Anna Louise ; Warthon Medina, Marisol ; Serra-Majem, Lluis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Databases, Factual</topic><topic>Dietary Supplements</topic><topic>Europe</topic><topic>EURRECA</topic><topic>Humans</topic><topic>Infant</topic><topic>infants</topic><topic>Nutritional Status</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review</topic><topic>serum/plasma Zn status</topic><topic>Zinc - administration &amp; dosage</topic><topic>Zinc - blood</topic><topic>Zinc - pharmacokinetics</topic><topic>zinc intake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nissensohn, Mariela</creatorcontrib><creatorcontrib>Sánchez Villegas, Almudena</creatorcontrib><creatorcontrib>Fuentes Lugo, Daniel</creatorcontrib><creatorcontrib>Henríquez Sánchez, Patricia</creatorcontrib><creatorcontrib>Doreste Alonso, Jorge</creatorcontrib><creatorcontrib>Lowe, Nicola M.</creatorcontrib><creatorcontrib>Hall Moran, Victoria</creatorcontrib><creatorcontrib>Skinner, Anna Louise</creatorcontrib><creatorcontrib>Warthon Medina, Marisol</creatorcontrib><creatorcontrib>Serra-Majem, Lluis</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Maternal and child nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nissensohn, Mariela</au><au>Sánchez Villegas, Almudena</au><au>Fuentes Lugo, Daniel</au><au>Henríquez Sánchez, Patricia</au><au>Doreste Alonso, Jorge</au><au>Lowe, Nicola M.</au><au>Hall Moran, Victoria</au><au>Skinner, Anna Louise</au><au>Warthon Medina, Marisol</au><au>Serra-Majem, Lluis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis</atitle><jtitle>Maternal and child nutrition</jtitle><addtitle>Matern Child Nutr</addtitle><date>2013-07</date><risdate>2013</risdate><volume>9</volume><issue>3</issue><spage>285</spage><epage>298</epage><pages>285-298</pages><issn>1740-8695</issn><issn>1740-8709</issn><eissn>1740-8709</eissn><abstract>A systematic review and meta‐analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta‐analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled β of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2 = 98%; P = 0.00001). When we performed a meta‐regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (P ANCOVA = 0.054; &lt;0.001 and &lt;0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4–20 weeks and &gt;20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12 mg day−1. In all cases, the pooled β showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence‐based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23647725</pmid><doi>10.1111/mcn.12045</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1740-8695
ispartof Maternal and child nutrition, 2013-07, Vol.9 (3), p.285-298
issn 1740-8695
1740-8709
1740-8709
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6860590
source PubMed Central
subjects Databases, Factual
Dietary Supplements
Europe
EURRECA
Humans
Infant
infants
Nutritional Status
Randomized Controlled Trials as Topic
Review
serum/plasma Zn status
Zinc - administration & dosage
Zinc - blood
Zinc - pharmacokinetics
zinc intake
title Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A33%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20zinc%20intake%20on%20serum/plasma%20zinc%20status%20in%20infants:%20a%20meta-analysis&rft.jtitle=Maternal%20and%20child%20nutrition&rft.au=Nissensohn,%20Mariela&rft.date=2013-07&rft.volume=9&rft.issue=3&rft.spage=285&rft.epage=298&rft.pages=285-298&rft.issn=1740-8695&rft.eissn=1740-8709&rft_id=info:doi/10.1111/mcn.12045&rft_dat=%3Cproquest_pubme%3E1366578935%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4535-fe94c8d2ec8f2ae6a4efbbeb0e1bacdc39bd6ae10c83e85687b8b52124d99bd53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1366578935&rft_id=info:pmid/23647725&rfr_iscdi=true