Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

Aims/hypothesis Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adu...

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Published in:Diabetologia 2019-12, Vol.62 (12), p.2298-2309
Main Authors: Ahola-Olli, Ari V., Mustelin, Linda, Kalimeri, Maria, Kettunen, Johannes, Jokelainen, Jari, Auvinen, Juha, Puukka, Katri, Havulinna, Aki S., Lehtimäki, Terho, Kähönen, Mika, Juonala, Markus, Keinänen-Kiukaanniemi, Sirkka, Salomaa, Veikko, Perola, Markus, Järvelin, Marjo-Riitta, Ala-Korpela, Mika, Raitakari, Olli, Würtz, Peter
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers - blood
Blood Glucose - metabolism
Cholesterol
Cholesterol - blood
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Fasting
Fatty Acids - blood
Female
Finland - epidemiology
Glucose
High density lipoprotein
Human Physiology
Humans
Hyperglycemia
Incidence
Insulin
Insulin - blood
Insulin Resistance - physiology
Internal Medicine
Laboratory testing
Lipoproteins (very low density)
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Metabolites
Metabolomics
Middle Aged
NMR
Nuclear magnetic resonance
Phenylalanine
Phenylalanine - blood
Risk
Young Adult
Young adults
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Summary:Aims/hypothesis Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults. Methods NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24–45 years). Associations between baseline metabolites and risk of developing diabetes during 8–15 years of follow-up (392 incident cases) were adjusted for sex, age, BMI and fasting glucose. Prospective metabolite associations were also tested with fasting glucose, 2 h glucose and HOMA-IR at follow-up. Results Out of 229 metabolic measures, 113 were associated with incident type 2 diabetes in meta-analysis of the four cohorts (ORs per 1 SD: 0.59–1.50; p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-019-05001-w