Indirect Effects of 10-Valent Pneumococcal Conjugate Vaccine Against Adult Pneumococcal Pneumonia in Rural Western Kenya

Abstract Background Data on pneumococcal conjugate vaccine (PCV) indirect effects in low-income countries with high human immunodeficiency virus (HIV) burden are limited. We examined adult pneumococcal pneumonia incidence before and after PCV introduction in Kenya in 2011. Methods From 1 January 200...

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Bibliographic Details
Published in:Clinical infectious diseases 2019-11, Vol.69 (12), p.2177-2184
Main Authors: Bigogo, Godfrey M., Audi, Allan, Auko, Joshua, Aol, George O., Ochieng, Benjamin J., Odiembo, Herine, Odoyo, Arthur, Widdowson, Marc-Alain, Onyango, Clayton, Borgdorff, Martien W., Feikin, Daniel R., da Gloria Carvalho, Maria, Whitney, Cynthia G., Verani, Jennifer R.
Format: Article
Language:English
Subjects:
Adult
ARTICLES AND COMMENTARIES
Coinfection
Female
HIV Infections - epidemiology
Humans
Incidence
Kenya - epidemiology
Male
Middle Aged
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - immunology
Pneumonia, Pneumococcal - epidemiology
Pneumonia, Pneumococcal - prevention & control
Public Health Surveillance
Rural Population
Streptococcus pneumoniae - immunology
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - immunology
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Summary:Abstract Background Data on pneumococcal conjugate vaccine (PCV) indirect effects in low-income countries with high human immunodeficiency virus (HIV) burden are limited. We examined adult pneumococcal pneumonia incidence before and after PCV introduction in Kenya in 2011. Methods From 1 January 2008 to 31 December 2016, we conducted surveillance for acute respiratory infection (ARI) among ~12 000 adults (≥18 years) in western Kenya, where HIV prevalence is ~17%. ARI cases (cough or difficulty breathing or chest pain, plus temperature ≥38.0°C or oxygen saturation
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz139