Pre-treatment systemic immune-inflammation represents a prognostic factor in patients with advanced non-small cell lung cancer

Inflammation plays an important role in pathogenesis, development and progression of lung cancer. The aim of the study is to assess the prognostic role of Systemic Immune-Inflammation Index (SII), obtained by analyzing the neutrophil, lymphocyte and platelet counts, and to design prognostic models f...

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Published in:Annals of translational medicine 2019-10, Vol.7 (20), p.572-572
Main Authors: Berardi, Rossana, Santoni, Matteo, Rinaldi, Silvia, Bower, Marc, Tiberi, Michela, Morgese, Francesca, Caramanti, Miriam, Savini, Agnese, Ferrini, Consuelo, Torniai, Mariangela, Fiordoliva, Ilaria, Newsom-Davis, Thomas
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Language:English
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Summary:Inflammation plays an important role in pathogenesis, development and progression of lung cancer. The aim of the study is to assess the prognostic role of Systemic Immune-Inflammation Index (SII), obtained by analyzing the neutrophil, lymphocyte and platelet counts, and to design prognostic models for patients receiving first-line chemo- or targeted therapy for advanced non-small cell lung cancer (NSCLC). We conducted an analysis on 311 patients with advanced NSCLC, treated with first line chemo- or targeted therapy till June 2015 at our Institution. Patients were stratified in two groups with SII ≥1,270 (Group A) SII
ISSN:2305-5839
2305-5839
DOI:10.21037/atm.2019.09.18