TOB1‑AS1 suppresses non‑small cell lung cancer cell migration and invasion through a ceRNA network

Non-small cell lung cancer (NSCLC) is the leading cause of lung cancer-associated mortality. Recent studies revealed that long non-coding (lnc)RNAs have crucial roles in human cancers. The present study was the first, to the best of our knowledge, to indicate that the lncRNA transducer of ERBB2, 1-a...

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Published in:Experimental and therapeutic medicine 2019-12, Vol.18 (6), p.4249-4258
Main Authors: Shangguan, Wen-Ji, Liu, Hai-Tao, Que, Zu-Jun, Qian, Fang-Fang, Liu, Ling- Shuang, Tian, Jian-Hui
Format: Article
Language:English
Subjects:
Bioinformatics
Biomarkers
Cancer metastasis
Cell adhesion & migration
Cell cycle
Cell growth
Cervical cancer
Dynein
Gene expression
Health aspects
Inositol
Kinases
Ligases
Lung cancer
Medical research
Metastasis
MicroRNA
MicroRNAs
Mortality
Non-small cell lung cancer
Novels
RNA
Roles
Scientific equipment industry
Small cell lung cancer
Transfer RNA
Tumors
Ubiquitin
United States
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Summary:Non-small cell lung cancer (NSCLC) is the leading cause of lung cancer-associated mortality. Recent studies revealed that long non-coding (lnc)RNAs have crucial roles in human cancers. The present study was the first, to the best of our knowledge, to indicate that the lncRNA transducer of ERBB2, 1-antisense 1 (TOB1-AS1) acts as a tumor suppressor in NSCLC. Knockdown of TOB1-AS1 significantly induced NSCLC cell migration, invasion and proliferation. It was also demonstrated that the higher expression of TOB1-AS1 in NSCLC samples was associated with longer overall survival time. Furthermore, a TOB1-AS1-mediated competing endogenous RNA network in NSCLC was constructed, including Homo sapiens (hsa)-microRNA (miR)-27a-3p, hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-27b-3p, hsa-miR-23c, dynein cytoplasmic 2 light intermediate chain 1, E4F transcription factor 1, TSPY-like 4, component of oligomeric Golgi complex 7, inositol hexakisphosphate kinase 2 and deltex E3 ubiquitin ligase 3. Of note, dysregulation of targets of TOB1-AS1 was associated with the prognosis of NSCLC patients. The present study suggested that TOB1-AS1 may serve as a novel biomarker for NSCLC.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2019.8103