The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats

• Published in: Behavioural brain research 2019-09, Vol.370, p.111953-111953, Article 111953
• Main Authors: Boyko, Matthew, Kutz, Ruslan, Grinshpun, Julia, Zvenigorodsky, Vladislav, Gruenbaum, Benjamin F., Gruenbaum, Shaun E., Frenkel, Amit, Brotfain, Evgeni, Israel Melamed, Frank, Dmitry, Zeldetz, Vladimir, Zlotnik, Alexander
• Format: Article
• Language: English
• Subjects: Animals; Antidepressive Agents - pharmacology; Behavior; Behavior, Animal - drug effects; Depression; Depression - drug therapy; Depression - psychology; Depressive Disorder - psychology; Depressive Disorder - therapy; Disease Models, Animal; Hierarchy, Social; Imipramine - pharmacology; Male; Psychotherapy - methods; Rats; Rats, Sprague-Dawley; Social Behavior; Social dynamics
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2019.111953

•Rats induced with depressive-like symptoms were significantly more active and aggressive in all parameters of the social organization test.•Antidepressant treatment was effective in influencing the social behaviors in rats with depressive-like symptoms.•Depressive-like behavior induced in this experiment was not accompanied by anxiety-like behavior. Depression-induced rats receiving antidepressant treatment exhibited similar performance on social behavioral tests to naïve rats. Depression is common and results in a significant morbidity and economic burden. Depression is associated with pervasive impairments in social functioning, and antidepressant treatments are highly variable in improving these impairments. The objectives of this study were to test the effects of depression on social organization and behavior in a rodent model of depression, and to study the effectiveness of antidepressant medication in improving both symptoms of depression and the social function of depressed animals. One hundred-twenty male Sprague-Dawley rats were randomly and equally divided between the control group and depression group. After induction of depression by 5 weeks of chronic unpredictable stress, rats received either antidepressant treatment or placebo. In parallel with the initiation of drug therapy, 20 social groups of six rats were subjected to the complex diving-for-food situation to evaluate their social functioning. Four behavioral tests evaluated symptoms of depression and anxiety at 3 different time points. We found that 1) depressed rats were significantly more active and aggressive in all parameters of social organization test compared with the control and antidepressant treatment groups, 2) depressed rats that received antidepressant treatment exhibited social behaviors like the control group, and 3) depression in the experimental groups was not accompanied by symptoms of anxiety. These results suggest that depression can significantly alter the social behavior and hierarchy in the social group in rats. Investigations of complex social group dynamics offer novel opportunities for translational studies of mood and psychiatric disorders.