The Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer

Background Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well-defined by the International Tumour Budding Consensus Conference (ITBCC). Objective The aim of the present study was to use the ITBCC budding evaluation method to examine the relationsh...

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Bibliographic Details
Published in:Annals of surgical oncology 2019-12, Vol.26 (13), p.4397-4404
Main Authors: van Wyk, Hester C., Roseweir, Antonia, Alexander, Peter, Park, James H., Horgan, Paul G., McMillan, Donald C., Edwards, Joanne
Format: Article
Language:English
Subjects:
Aged
Cancer
Colorectal Cancer
Colorectal carcinoma
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Female
Humans
Inflammation
Male
Medicine
Medicine & Public Health
Middle Aged
Mismatch repair
Neoplasm Invasiveness
Neoplasm Staging
Oncology
Prognosis
Prospective Studies
Stroma
Surgery
Surgical Oncology
Survival Rate
Tumor Microenvironment
Tumors
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Summary:Background Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well-defined by the International Tumour Budding Consensus Conference (ITBCC). Objective The aim of the present study was to use the ITBCC budding evaluation method to examine the relationship between tumor budding, tumor factors, tumor microenvironment, and survival in patients with primary operable CRC. Methods Hematoxylin and eosin-stained slides of 952 CRC patients diagnosed between 1997 and 2007 were evaluated for tumor budding according to the ITBCC criteria. The tumor microenvironment was evaluated using tumor stroma percentage (TSP) and Klintrup–Makinen (KM) grade to assess the tumor inflammatory cell infiltrate. Results High budding ( n  = 268, 28%) was significantly associated with TNM stage ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-019-07931-6