Practical recommendations to conduct a neuroimaging meta‐analysis for neuropsychiatric disorders

Over the past decades, neuroimaging has become widely used to investigate structural and functional brain abnormality in neuropsychiatric disorders. The results of individual neuroimaging studies, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, an...

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Bibliographic Details
Published in:Human brain mapping 2019-12, Vol.40 (17), p.5142-5154
Main Authors: Tahmasian, Masoud, Sepehry, Amir A., Samea, Fateme, Khodadadifar, Tina, Soltaninejad, Zahra, Javaheripour, Nooshin, Khazaie, Habibolah, Zarei, Mojtaba, Eickhoff, Simon B., Eickhoff, Claudia R.
Format: Article
Language:English
Subjects:
Brain
Brain - diagnostic imaging
Disorders
guideline
Heterogeneity
Humans
Image processing
Medical imaging
Mental disorders
Mental Disorders - diagnostic imaging
Meta-analysis
Meta-Analysis as Topic
Neuroimaging
Neurology
neuropsychiatric disorders
Research Design
Review
Statistical analysis
Statistical methods
Structure-function relationships
systematic review
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Summary:Over the past decades, neuroimaging has become widely used to investigate structural and functional brain abnormality in neuropsychiatric disorders. The results of individual neuroimaging studies, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings. To consolidate the emergent findings toward clinically useful insight, meta‐analyses have been developed to integrate the results of studies and identify areas that are consistently involved in pathophysiology of particular neuropsychiatric disorders. However, it should be considered that the results of meta‐analyses could also be divergent due to heterogeneity in search strategy, selection criteria, imaging modalities, behavioral tasks, number of experiments, data organization methods, and statistical analysis with different multiple comparison thresholds. Following an introduction to the problem and the concepts of quantitative summaries of neuroimaging findings, we propose practical recommendations for clinicians and researchers for conducting transparent and methodologically sound neuroimaging meta‐analyses. This should help to consolidate the search for convergent regional brain abnormality in neuropsychiatric disorders.
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.24746