Early detection of Alzheimer's disease using MRI hippocampal texture

Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippoc...

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Bibliographic Details
Published in:Human brain mapping 2016-03, Vol.37 (3), p.1148-1161
Main Authors: Sørensen, Lauge, Igel, Christian, Liv Hansen, Naja, Osler, Merete, Lauritzen, Martin, Rostrup, Egill, Nielsen, Mads
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnosis
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Area Under Curve
biomarker
classification
Cognition
Cohort Studies
Databases, Factual
Early Diagnosis
Female
Glucose - metabolism
hippocampus
Hippocampus - diagnostic imaging
Hippocampus - metabolism
Hippocampus - pathology
Humans
image analysis
Image Interpretation, Computer-Assisted - methods
machine learning
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
mild cognitive impairment
Organ Size
Positron-Emission Tomography
Prognosis
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Summary:Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippocampal volume. We tested the hypothesis that hippocampal texture has association to early cognitive loss beyond that of volumetric changes. The texture marker was trained and evaluated using T1‐weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, and subsequently applied to score independent data sets from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) and the Metropolit 1953 Danish Male Birth Cohort (Metropolit). Hippocampal texture was superior to volume reduction as predictor of MCI‐to‐AD conversion in ADNI (area under the receiver operating characteristic curve [AUC] 0.74 vs 0.67; DeLong test, p = 0.005), and provided even better prognostic results in AIBL (AUC 0.83). Hippocampal texture, but not volume, correlated with Addenbrooke's cognitive examination score (Pearson correlation, r = −0.25, p 
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.23091