Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues

Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two represent...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2019-11, Vol.33 (9), p.e22984-n/a
Main Authors: Lu, Rongdan, Shao, Yongfu, Tao, Xueping, Ye, Guoliang, Xiao, Bingxiu, Guo, Junming
Format: Article
Language:English
Subjects:
circular RNA
clinical significance
Down-Regulation - genetics
Female
gastric cancer
Gene Expression Regulation, Neoplastic
Hsa_circ_0005758
Hsa_circ_0067582
Humans
Male
Middle Aged
RNA, Circular - genetics
RNA, Circular - metabolism
ROC Curve
Stomach Neoplasms - genetics
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Summary:Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients. Methods Using real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758. Results Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.22984