Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues

Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two represent...

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Published in:Journal of clinical laboratory analysis 2019-11, Vol.33 (9), p.e22984-n/a
Main Authors: Lu, Rongdan, Shao, Yongfu, Tao, Xueping, Ye, Guoliang, Xiao, Bingxiu, Guo, Junming
Format: Article
Language:English
Subjects:
circular RNA
clinical significance
Down-Regulation - genetics
Female
gastric cancer
Gene Expression Regulation, Neoplastic
Hsa_circ_0005758
Hsa_circ_0067582
Humans
Male
Middle Aged
RNA, Circular - genetics
RNA, Circular - metabolism
ROC Curve
Stomach Neoplasms - genetics
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cited_by cdi_FETCH-LOGICAL-c4204-53a7959d9c9cf42dabc361493b72252dd9f922d8260ce0b36592c7a348a11af13
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container_issue 9
container_start_page e22984
container_title Journal of clinical laboratory analysis
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creator Lu, Rongdan
Shao, Yongfu
Tao, Xueping
Ye, Guoliang
Xiao, Bingxiu
Guo, Junming
description Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients. Methods Using real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758. Results Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P
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However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients. Methods Using real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758. Results Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P &lt;.001) and stages (P = .037); and hsa_circ_0005758 expression was relevant to tissue CEA level (P &lt; .001) and perineural invasion (P = .048). The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.671. The cutoff value was set at 10.61, with which the sensitivity and specificity were 55.2% and 75.0%, respectively. Similar to hsa_circ_0005758, the AUC of hsa_circ_0005758 was 0.721. The cutoff value was set at 10.20, with which the sensitivity and specificity were 75.0% and 67.7%, respectively. Conclusion These results showed that both hsa_circ_0067582 and hsa_circ_0005758 may play an important role in gastric carcinogenesis; and they may be potential indicators for GC diagnosis.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.22984</identifier><identifier>PMID: 31328820</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>circular RNA ; clinical significance ; Down-Regulation - genetics ; Female ; gastric cancer ; Gene Expression Regulation, Neoplastic ; Hsa_circ_0005758 ; Hsa_circ_0067582 ; Humans ; Male ; Middle Aged ; RNA, Circular - genetics ; RNA, Circular - metabolism ; ROC Curve ; Stomach Neoplasms - genetics</subject><ispartof>Journal of clinical laboratory analysis, 2019-11, Vol.33 (9), p.e22984-n/a</ispartof><rights>2019 The Authors Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4204-53a7959d9c9cf42dabc361493b72252dd9f922d8260ce0b36592c7a348a11af13</citedby><cites>FETCH-LOGICAL-c4204-53a7959d9c9cf42dabc361493b72252dd9f922d8260ce0b36592c7a348a11af13</cites><orcidid>0000-0003-2026-1075 ; 0000-0002-8592-9251 ; 0000-0003-0600-9981</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868420/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868420/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11561,27923,27924,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31328820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Rongdan</creatorcontrib><creatorcontrib>Shao, Yongfu</creatorcontrib><creatorcontrib>Tao, Xueping</creatorcontrib><creatorcontrib>Ye, Guoliang</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><title>Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients. Methods Using real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758. Results Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P &lt;.001) and stages (P = .037); and hsa_circ_0005758 expression was relevant to tissue CEA level (P &lt; .001) and perineural invasion (P = .048). The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.671. The cutoff value was set at 10.61, with which the sensitivity and specificity were 55.2% and 75.0%, respectively. Similar to hsa_circ_0005758, the AUC of hsa_circ_0005758 was 0.721. The cutoff value was set at 10.20, with which the sensitivity and specificity were 75.0% and 67.7%, respectively. Conclusion These results showed that both hsa_circ_0067582 and hsa_circ_0005758 may play an important role in gastric carcinogenesis; and they may be potential indicators for GC diagnosis.</description><subject>circular RNA</subject><subject>clinical significance</subject><subject>Down-Regulation - genetics</subject><subject>Female</subject><subject>gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hsa_circ_0005758</subject><subject>Hsa_circ_0067582</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>RNA, Circular - genetics</subject><subject>RNA, Circular - metabolism</subject><subject>ROC Curve</subject><subject>Stomach Neoplasms - genetics</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kE1LAzEQhoMotlYv_gDJWdg6mexHchHK4icFL3rwFLLZbJuy3S1JVfrv3Xa11IunGWbe95nhJeSSwZgB4M3C1HqMKEV8RIYMpIhQYHJMhiBEFglgfEDOQlgAgJAsPSUDzjgKgTAk73ntGmd0TYObNa7q2sbYQNuKzoNWxnmjANIsEUh1Ux4OIemm1DV0psPaO0N3Vk_XLoQPG87JSaXrYC9-6oi83d-95o_R9OXhKZ9MIxMjxFHCdSYTWUojTRVjqQvDUxZLXmSICZalrCRiKTAFY6HgaSLRZJrHQjOmK8ZH5Lbnrj6KpS2NbdZe12rl3VL7jWq1U383jZurWfupUpGK7oUOcN0DjG9D8LbaexmobcBqG7DaBdyJrw6v7aW_iXYC1gu-XG03_6DUcz6d9NBvLviFaw</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Lu, Rongdan</creator><creator>Shao, Yongfu</creator><creator>Tao, Xueping</creator><creator>Ye, Guoliang</creator><creator>Xiao, Bingxiu</creator><creator>Guo, Junming</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2026-1075</orcidid><orcidid>https://orcid.org/0000-0002-8592-9251</orcidid><orcidid>https://orcid.org/0000-0003-0600-9981</orcidid></search><sort><creationdate>201911</creationdate><title>Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues</title><author>Lu, Rongdan ; Shao, Yongfu ; Tao, Xueping ; Ye, Guoliang ; Xiao, Bingxiu ; Guo, Junming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4204-53a7959d9c9cf42dabc361493b72252dd9f922d8260ce0b36592c7a348a11af13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>circular RNA</topic><topic>clinical significance</topic><topic>Down-Regulation - genetics</topic><topic>Female</topic><topic>gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hsa_circ_0005758</topic><topic>Hsa_circ_0067582</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>RNA, Circular - genetics</topic><topic>RNA, Circular - metabolism</topic><topic>ROC Curve</topic><topic>Stomach Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Rongdan</creatorcontrib><creatorcontrib>Shao, Yongfu</creatorcontrib><creatorcontrib>Tao, Xueping</creatorcontrib><creatorcontrib>Ye, Guoliang</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Rongdan</au><au>Shao, Yongfu</au><au>Tao, Xueping</au><au>Ye, Guoliang</au><au>Xiao, Bingxiu</au><au>Guo, Junming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2019-11</date><risdate>2019</risdate><volume>33</volume><issue>9</issue><spage>e22984</spage><epage>n/a</epage><pages>e22984-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_circ_0067582 and hsa_circ_0005758, to investigate their clinical significance in GC patients. Methods Using real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR), we explored the expression levels of hsa_circ_0067582 and hsa_circ_0005758 in tissues with different stages of gastric tumorigenesis. Then, the relationships between their expression levels and GC patients' clinicopathological factors were further investigated. Receiver operating characteristic (ROC) curves were established for evaluating diagnostic values of hsa_circ_0067582 and hsa_circ_0005758. Results Compared with healthy control tissues, both hsa_circ_0067582 and hsa_circ_0005758 were significantly decreased in GC tissues. Besides, hsa_circ_0067582 expression was associated with GC patients' tissue CEA level (P &lt;.001) and stages (P = .037); and hsa_circ_0005758 expression was relevant to tissue CEA level (P &lt; .001) and perineural invasion (P = .048). The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.671. The cutoff value was set at 10.61, with which the sensitivity and specificity were 55.2% and 75.0%, respectively. Similar to hsa_circ_0005758, the AUC of hsa_circ_0005758 was 0.721. The cutoff value was set at 10.20, with which the sensitivity and specificity were 75.0% and 67.7%, respectively. Conclusion These results showed that both hsa_circ_0067582 and hsa_circ_0005758 may play an important role in gastric carcinogenesis; and they may be potential indicators for GC diagnosis.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>31328820</pmid><doi>10.1002/jcla.22984</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2026-1075</orcidid><orcidid>https://orcid.org/0000-0002-8592-9251</orcidid><orcidid>https://orcid.org/0000-0003-0600-9981</orcidid><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Publicly Available Content (ProQuest); Wiley Open Access
subjects circular RNA
clinical significance
Down-Regulation - genetics
Female
gastric cancer
Gene Expression Regulation, Neoplastic
Hsa_circ_0005758
Hsa_circ_0067582
Humans
Male
Middle Aged
RNA, Circular - genetics
RNA, Circular - metabolism
ROC Curve
Stomach Neoplasms - genetics
title Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues
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