Altered temporal variance and neural synchronization of spontaneous brain activity in anesthesia

• Published in: Human brain mapping 2014-11, Vol.35 (11), p.5368-5378
• Main Authors: Huang, Zirui, Wang, Zhiyao, Zhang, Jianfeng, Dai, Rui, Wu, Jinsong, Li, Yuan, Liang, Weimin, Mao, Ying, Yang, Zhong, Holland, Giles, Zhang, Jun, Northoff, Georg
• Format: Article
• Language: English
• Subjects: Adult; Anesthesia; Anesthetics - administration & dosage; Biological and medical sciences; Brain - blood supply; Brain - drug effects; Brain Mapping; consciousness; cortical midline regions; Drug Administration Routes; Female; fMRI; functional connectivity; Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted; Investigative techniques, diagnostic techniques (general aspects); low-frequency fluctuations; Magnetic Resonance Imaging; Male; Medical sciences; Methyl Ethers - administration & dosage; Middle Aged; Models, Neurological; Nervous system; Oxygen - blood; Perception; Propofol - administration & dosage; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; resting state; Vision; Wakefulness
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.22556

Recent studies at the cellular and regional levels have pointed out the multifaceted importance of neural synchronization and temporal variance of neural activity. For example, neural synchronization and temporal variance has been shown by us to be altered in patients in the vegetative state (VS). This finding nonetheless leaves open the question of whether these abnormalities are specific to VS or rather more generally related to the absence of consciousness. The aim of our study was to investigate the changes of inter‐ and intra‐regional neural synchronization and temporal variance of resting state activity in anesthetic‐induced unconsciousness state. Applying an intra‐subject design, we compared resting state activity in functional magnetic resonance imaging (fMRI) between awake versus anesthetized states in the same subjects. Replicating previous studies, we observed reduced functional connectivity within the default mode network (DMN) and thalamocortical network in the anesthetized state. Importantly, intra‐regional synchronization as measured by regional homogeneity (ReHo) and temporal variance as measured by standard deviation (SD) of the BOLD signal were significantly reduced in especially the cortical midline regions, while increased in the lateral cortical areas in the anesthetized state. We further found significant frequency‐dependent effects of SD in the thalamus, which showed abnormally high SD in Slow‐5 (0.01–0.027 Hz) in the anesthetized state. Our results show for the first time of altered temporal variance of resting state activity in anesthesia. Combined with our findings in the vegetative state, these findings suggest a close relationship between temporal variance, neural synchronization and consciousness. Hum Brain Mapp 35:5368–5378, 2014. © 2014 Wiley Periodicals, Inc.