Comparison of diffusion tractography and tract-tracing measures of connectivity strength in rhesus macaque connectome

With the mapping of macroscale connectomes by means of in vivo diffusion‐weighted MR Imaging (DWI) rapidly gaining in popularity, one of the necessary steps is the examination of metrics of connectivity strength derived from these reconstructions. In the field of human macroconnectomics the number o...

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Bibliographic Details
Published in:Human brain mapping 2015-08, Vol.36 (8), p.3064-3075
Main Authors: van den Heuvel, Martijn P., de Reus, Marcel A., Feldman Barrett, Lisa, Scholtens, Lianne H., Coopmans, Fraukje M.T., Schmidt, Ruben, Preuss, Todd M., Rilling, James K., Li, Longchuan
Format: Article
Language:English
Subjects:
Animals
Atlases as Topic
Brain - anatomy & histology
connectivity
Connectome
connectomics
Databases, Factual
diffusion imaging
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging - methods
Female
Macaca mulatta
Macaca mulatta - anatomy & histology
macaque
Male
Neural Pathways - anatomy & histology
Neuroanatomical Tract-Tracing Techniques
tract tracing
white matter
White Matter - anatomy & histology
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Summary:With the mapping of macroscale connectomes by means of in vivo diffusion‐weighted MR Imaging (DWI) rapidly gaining in popularity, one of the necessary steps is the examination of metrics of connectivity strength derived from these reconstructions. In the field of human macroconnectomics the number of reconstructed fiber streamlines (NOS) is more and more used as a metric of cortico‐cortical interareal connectivity strength, but the link between DWI NOS and in vivo animal tract‐tracing measurements of anatomical connectivity strength remains poorly understood. In this technical report, we communicate on a comparison between DWI derived metrics and tract‐tracing metrics of projection strength. Tract‐tracing information on projection strength of interareal pathways was extracted from two commonly used macaque connectome datasets, including (1) the CoCoMac database of collated tract‐tracing experiments of the macaque brain and (2) the high‐resolution tract‐tracing dataset of Markov and Kennedy and coworkers. NOS and density of reconstructed fiber pathways derived from DWI data acquired across 10 rhesus macaques was found to positively correlate to tract‐tracing based measurements of connectivity strength across both the CoCoMac and Markov dataset (both P 
ISSN:1065-9471
1097-0193
1097-0193
DOI:10.1002/hbm.22828