Cortical brain responses during passive nonpainful median nerve stimulation at low frequencies (0.5-4 Hz): An fMRI study

• Published in: Human brain mapping 2007-07, Vol.28 (7), p.645-653
• Main Authors: Ferretti, Antonio, Babiloni, Claudio, Arienzo, Donatello, Del Gratta, Cosimo, Rossini, Paolo Maria, Tartaro, Armando, Romani, Gian Luca
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Brain Mapping; Dose-Response Relationship, Radiation; Electric Stimulation - methods; Electrodiagnosis. Electric activity recording; Evoked Potentials, Somatosensory - physiology; Female; functional magnetic resonance imaging (fMRI); Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Median Nerve - physiology; median nerve electrical stimulation; Medical sciences; Nervous system; Oxygen - blood; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reaction Time - radiation effects; secondary somatosensory cortex (SII); Somatosensory Cortex - blood supply; Somatosensory Cortex - physiology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; stimulus frequency; Vertebrates: nervous system and sense organs
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.20292

Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypothesis that these areas have different sensitivities to stimulation frequency in the condition of passive stimulation. Functional MRI (fMRI) was recorded in 24 normal volunteers during nonpainful electrical median nerve stimulations at 0.5, 1, 2, and 4 Hz repetition rates in separate recording blocks in pseudorandom order. Results of the blood oxygen level‐dependent (BOLD) effect showed that the contralateral SI, the bilateral SII, and the bilateral insula were active during these stimulations. As a major finding, only the contralateral SI increased its activation with the increase of the stimulus frequency at the mentioned range. The fact that nonpainful median‐nerve electrical stimuli at 4 Hz induces a larger BOLD response is of interest both for basic research and clinical applications in subjects unable to perform cognitive tasks in the fMRI scanner. Hum Brain Mapp 2006. © 2006 Wiley‐Liss, Inc.