Genetic components of functional connectivity in the brain: The heritability of synchronization likelihood

Cognitive functions require the integrated activity of multiple specialized, distributed brain areas. Such functional coupling depends on the existence of anatomical connections between the various brain areas as well as physiological processes whereby the activity in one area influences the activit...

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Bibliographic Details
Published in:Human brain mapping 2005-11, Vol.26 (3), p.191-198
Main Authors: Posthuma, Danielle, de Geus, Eco J.C., Mulder, Elles J.C.M., Smit, Dirk J.A., Boomsma, Dorret I., Stam, Cornelis J.
Format: Article
Language:English
Subjects:
Alpha Rhythm
Biological and medical sciences
Brain - growth & development
Brain - physiopathology
brain function
Cognition - physiology
Cortical Synchronization
EEG
Electrodiagnosis. Electric activity recording
Environment
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease - genetics
Genetic Testing
genetics
Human
Humans
Inheritance Patterns - physiology
Investigative techniques, diagnostic techniques (general aspects)
Learning
Learning. Memory
Male
Medical sciences
Nervous system
Neural Pathways - growth & development
Neural Pathways - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
twins
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Summary:Cognitive functions require the integrated activity of multiple specialized, distributed brain areas. Such functional coupling depends on the existence of anatomical connections between the various brain areas as well as physiological processes whereby the activity in one area influences the activity in another area. Recently, the Synchronization Likelihood (SL) method was developed as a general method to study both linear and nonlinear aspects of coupling. In the present study the genetic architecture of the SL in different frequency bands was investigated. Using a large genetically informative sample of 569 subjects from 282 extended twin families we found that the SL is moderately to highly heritable (41–67%) especially in the alpha frequency (8–13 Hz) range. This index of functional connectivity of the brain has been associated with a number of pathological states of the brain. The significant heritability found here suggests that SL can be used to examine the genetic susceptibility to these conditions. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.20156