Laterally Spreading Adenocarcinoma Involving the Lower Bile Duct and Duodenum Expressing Heterogeneous Immunohistochemical Phenotypes

A 70-year-old man was admitted to our hospital due to elevated levels of hepatobiliary and pancreatic enzymes. Computed tomography showed contrast-enhanced mucosal hypertrophy from the duodenal papilla to the distal bile duct. Endoscopic examinations revealed a laterally spreading granular tumor and...

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Bibliographic Details
Published in:Internal Medicine 2019/11/01, Vol.58(21), pp.3087-3092
Main Authors: Miyabe, Katsuyuki, Notohara, Kenji, Asano, Go, Kachi, Kenta, Kato, Akihisa, Natsume, Makoto, Jinno, Naruomi, Hori, Yasuki, Yoshida, Michihiro, Naitoh, Itaru, Hayashi, Kazuki, Ohara, Hirotaka, Takahashi, Satoru, Kataoka, Hiromi
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenoma
Adenoma - pathology
Adenoma - surgery
Aged
Ampulla of Vater
ampullary adenocarcinoma
Bile
bile duct
Bile ducts
Case Report
Common Bile Duct - diagnostic imaging
Common Bile Duct - pathology
Common Bile Duct Neoplasms - pathology
Common Bile Duct Neoplasms - surgery
Computed tomography
different phenotypes
Duodenal Neoplasms - diagnostic imaging
Duodenal Neoplasms - pathology
Duodenal Neoplasms - surgery
Duodenum
Duodenum - diagnostic imaging
Duodenum - pathology
Humans
Hypertrophy
Internal medicine
Invasiveness
laterally spreading tumor
Male
Mucosa
Neoplasm Invasiveness
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Pancreas
Phenotypes
Tomography, X-Ray Computed
Citations: Items that this one cites
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Description
Summary:A 70-year-old man was admitted to our hospital due to elevated levels of hepatobiliary and pancreatic enzymes. Computed tomography showed contrast-enhanced mucosal hypertrophy from the duodenal papilla to the distal bile duct. Endoscopic examinations revealed a laterally spreading granular tumor and ampullary swelling. After surgical resection, an examination revealed well-differentiated adenocarcinoma of the ampulla with tubular adenoma spreading from the distal common bile duct to the second part of the duodenum showing both bile duct and duodenal phenotypes. To our knowledge, this is the first case of a tumor spreading from the bile duct to the duodenum that exhibited multiple phenotypes.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2801-19