Tissue factor expression predicts outcome in children with neuroblastoma: A retrospective study

Previous studies have revealed that the processes of tumor angiogenesis, metastasis and invasiveness are highly dependent on components of the blood coagulation cascade. Tissue factor (TF) is one of the key proteins in coagulation. Cumulative evidence suggested that in addition to its role in coagul...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2019-12, Vol.18 (6), p.6347-6354
Main Authors: Sherief, Laila M, Hassan, Tamer H, Zakaria, Marwa, Fathy, Manar, Eshak, Elia A, Bebars, Marwa A, Esh, Asmaa
Format: Article
Language:English
Subjects:
Age
Biotechnology
Cancer therapies
Chemotherapy
Clinical outcomes
Ethanol
Males
Medical prognosis
Metastasis
Mortality
Neuroblastoma
Pathology
Patients
Pediatrics
Studies
Transcription factors
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have revealed that the processes of tumor angiogenesis, metastasis and invasiveness are highly dependent on components of the blood coagulation cascade. Tissue factor (TF) is one of the key proteins in coagulation. Cumulative evidence suggested that in addition to its role in coagulation, TF regulates intracellular signaling pathways that serve an important role in angiogenesis, tumor development and metastasis. In the present study, TF expression in neuroblastoma as well as its association with tumor stage, pathology and outcome were assessed. A total of 40 formalin-fixed paraffin-embedded tissues were evaluated for TF expression by immunohistochemical analysis. Results revealed that TF expression was positive in 75% of the analyzed tumor tissues. No significant association between TF expression and sex, age, tumor stage or disease pathology was observed. MYCN proto-oncogene bHLH transcription factor (MYCN) was upregulated in 45% (n=18) of the study cases. Positive TF expression was observed in 94.4% of patients (n=17) with upregulated MYCN, while 59% of patients (n=13) with normal MYCN showed positive TF expression (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2019.11021