A Novel Clinical Six-Flavoprotein-Gene Signature Predicts Prognosis in Esophageal Squamous Cell Carcinoma

Flavoproteins and their interacting proteins play important roles in mitochondrial electron transport, fatty acid degradation, and redox regulation. However, their clinical significance and function in esophageal squamous cell carcinoma (ESCC) are little known. Here, using survival analysis and mach...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2019, Vol.2019 (2019), p.1-13
Main Authors: Li, Enmin, Zhao, Jian-Mei, Pan, Feng, Long, Lin, Guo, Jin-Cheng, Peng, Liu, Xu, Liyan
Format: Article
Language:English
Subjects:
Algorithms
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
Cell migration
Cell Movement
Cell Proliferation
Dehydrogenases
DNA methylation
Electron transport
Enzymes
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Squamous Cell Carcinoma - genetics
Esophageal Squamous Cell Carcinoma - metabolism
Esophagus
Fatty acids
Female
Flavoproteins
Flavoproteins - genetics
Flavoproteins - metabolism
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Gene Knockdown Techniques
Genes
Genetic aspects
Genomes
Glycerol
Humans
Kaplan-Meier Estimate
Kinases
Learning algorithms
Machine Learning
Male
Medical prognosis
Medical research
Metabolism
Metastasis
Middle Aged
Mitochondria
Nutrition research
Oxidoreductases Acting on Sulfur Group Donors - genetics
Polymerase chain reaction
Predictions
Prognosis
Proteins
Risk
Risk groups
RNA, Messenger - metabolism
RNA-mediated interference
Squamous cell carcinoma
Src protein
Studies
Survival
Survival Analysis
Time dependence
Transcriptome
Vitamin B
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Flavoproteins and their interacting proteins play important roles in mitochondrial electron transport, fatty acid degradation, and redox regulation. However, their clinical significance and function in esophageal squamous cell carcinoma (ESCC) are little known. Here, using survival analysis and machine learning, we mined 179 patient expression profiles with ESCC in GSE53625 from the Gene Expression Omnibus (GEO) database and constructed a signature consisting of two flavoprotein genes (GPD2 and PYROXD2) and four flavoprotein interacting protein genes (CTTN, GGH, SRC, and SYNJ2BP). Kaplan–Meier analysis revealed the signature was significantly associated with the survival of ESCC patients (mean survival time: 26.77 months in the high-risk group vs. 54.97 months in the low-risk group, P
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/3869825