Precision Medicine and the Practice of Trichiatry: Adapting the Concept

• Published in: Skin appendage disorders 2019-11, Vol.5 (6), p.338-343
• Main Authors: Trüeb, Ralph M., Jolliffe, Vicky M.L., Régnier, Antonia Fellas, Dutra Rezende, Hudson, Vañó-Galván, Sergio, Kopera, Daisy, Ioannides, Demetrios, Gavazzoni Dias, Maria Fernanda Reis, Macpherson, Melanie, Gadzhigoroeva, Aida, Ovcharenko, Julya, Lee, Won-Soo, Murugusundram, Sundaram, Kurata, Sotaro, Chang, Mimi, Tanglertsampan, Chuchai
• Format: Article
• Language: English
• Subjects: Guidelines
• ISSN: 2296-9195; 2296-9160
• DOI: 10.1159/000500364

Evidence-based medicine (EBM) aims for the ideal that healthcare professionals make conscientious, explicit, and judicious use of the best available evidence gained from the scientific method to clinical decision-making. It seeks to assess the strength of the evidence for benefits of diagnostic tests and treatments, using techniques from science, engineering, and statistics, such as the systematic review of medical literature, meta-analysis, risk-benefit analysis, and randomized controlled trials. The limited success rate of EBM therapies suggests that the complex nature of hair loss may be inadequately served by the present levels of evidence, and that physicians treating hair loss may have fallen short of adequately researching a robust evidence to underpin their practices. Against this backdrop, the concept of precision medicine (PM) is evolving. PM refers to the customization of medical care to the patient’s individual characteristics based on the patient’s genetic background and other molecular or cellular analysis, while classifying patients into subpopulations that differ in their susceptibility to a particular medical condition, in the biology or prognosis of those medical conditions, or in their response to a specific treatment. With the advances in hair research, the powerful tools of molecular biology and genetics, and innovative technologies, we have the robust scientific data and tools to adapt the concept of PM to the practice of trichiatry. Finally, databases pertaining to the development and efficacy of PM must be analyzed and be used to form the basis of evidence-based personalized trichiatry.