Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer

The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcom...

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Bibliographic Details
Published in:Disease markers 2019, Vol.2019 (2019), p.1-5
Main Authors: Pitta, Maira Galdino da Rocha, de Melo Rego, Moacyr Jesus Barreto, Lucena-Araujo, Antônio Roberto, Martins, Mário Rino, Cordeiro, Marina Ferraz, de Souza Albuquerque, Mário Sérgio, Quirino, Michael Williams Leal, de Barros Albuquerque, Amanda Pinheiro, da Silva Filho, Antônio Felix, de Souza, Maria de Fátima Deodato, Pitta, Ivan da Rocha
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - metabolism
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Adult
Age
Aged
Aged, 80 and over
Biomarkers
Biomarkers, Tumor - metabolism
Cancer
Cell Differentiation
Cellulose
Classification
Combined Modality Therapy
Development and progression
Dextrose
Disease
Enzymes
Epimerase
Female
Follow-Up Studies
Gastric cancer
Gene expression
Glucose
Glycosylation
Glycosyltransferase
Humans
Immunohistochemistry
Lipids
Lymphatic Metastasis
Lymphatic system
Lymphoma
Male
Medical research
Metabolism
Metabolites
Metastasis
Middle Aged
mRNA
Neoplasm Grading
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Parameters
Radiation therapy
RNA
Statistical analysis
Stomach cancer
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
Thyroid cancer
Tumors
UDPglucose 4-Epimerase - metabolism
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Summary:The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative. Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p0.05). Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/6325326