Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?

• Published in: International journal of molecular sciences 2019-11, Vol.20 (22), p.5794
• Main Authors: Iglesia, Rebeca Piatniczka, Fernandes, Camila Felix de Lima, Coelho, Bárbara Paranhos, Prado, Mariana Brandão, Melo Escobar, Maria Isabel, Almeida, Gustavo Henrique Doná Rodrigues, Lopes, Marilene Hohmuth
• Format: Article
• Language: English
• Subjects: Angiogenesis; Antigen presentation; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Biology; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Cancer therapies; CD3 antigen; Cell activation; Cell growth; Cell proliferation; Chaperones; Cytochrome; Disease Progression; Gelatinase A; Gene Expression Regulation, Neoplastic - drug effects; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - metabolism; Growth factors; Heat shock proteins; Heat-Shock Proteins - drug effects; Heat-Shock Proteins - metabolism; Hsp70 protein; Hsp72 protein; Hsp90 protein; Humans; Hypoxia; Inflammation; Leukemia; Liver cancer; Lymphocytes T; Medical prognosis; Metastases; Metastasis; Molecular Targeted Therapy; Neuroendocrine tumors; Ovarian cancer; Pancreas; Patients; Review; Roles; Self sufficiency; Stem cells; Transcription factors; Tumor cells; Tumors
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20225794

Heat shock proteins (HSPs) are evolutionary conserved proteins that work as molecular chaperones and perform broad and crucial roles in proteostasis, an important process to preserve the integrity of proteins in different cell types, in health and disease. Their function in cancer is an important aspect to be considered for a better understanding of disease development and progression. Glioblastoma (GBM) is the most frequent and lethal brain cancer, with no effective therapies. In recent years, HSPs have been considered as possible targets for GBM therapy due their importance in different mechanisms that govern GBM malignance. In this review, we address current evidence on the role of several HSPs in the biology of GBMs, and how these molecules have been considered in different treatments in the context of this disease, including their activities in glioblastoma stem-like cells (GSCs), a small subpopulation able to drive GBM growth. Additionally, we highlight recent works that approach other classes of chaperones, such as histone and mitochondrial chaperones, as important molecules for GBM aggressiveness. Herein, we provide new insights into how HSPs and their partners play pivotal roles in GBM biology and may open new therapeutic avenues for GBM based on proteostasis machinery.