p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer

Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, espe...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-11, Vol.20 (22), p.5781
Main Authors: Smirnov, Artem, Anemona, Lucia, Novelli, Flavia, Piro, Cristina M, Annicchiarico-Petruzzelli, Margherita, Melino, Gerry, Candi, Eleonora
Format: Article
Language:English
Subjects:
Adherens junctions
Basal cell carcinoma
Biomarkers, Tumor - metabolism
Cadherin
Carcinoma, Basal Cell - diagnosis
Carcinoma, Basal Cell - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Cell differentiation
Cell proliferation
Codification
Cyclin-dependent kinase
Cyclin-dependent kinases
Enzyme inhibitors
Filaments
Gene expression
Gene regulation
Genes
Hair
Hemidesmosomes
Humans
Immunohistochemistry
Intermediate filaments
Keratin
Keratinocytes
Kinases
Melanoma - diagnosis
Melanoma - metabolism
Prognosis
Proteins
Review
Risk analysis
Risk factors
Skin cancer
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Squamous cell carcinoma
Stem cells
Transcription
Transcription factors
Transcription Factors - metabolism
Tumor Suppressor Proteins - metabolism
Tumorigenesis
Tumors
Ultraviolet radiation
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Summary:Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case of melanoma. Therefore, good diagnostic and prognostic markers are needed to ensure correct detection and treatment. Transcription factor p63, a member of the p53 family of proteins, plays an essential role in the development of stratified epithelia such as skin. In this paper, we conduct a comprehensive review of p63 expression in different types of skin cancer and discuss its possible use in the diagnosis and prognosis of cutaneous tumours.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20225781