The impact of renal function on efficacy and safety of new oral anticoagulant in atrial fibrillation patients: A systemic review and meta-analysis

This meta-analysis was to investigate the efficacy and safety of new oral anticoagulant (NOAC) in atrial fibrillation (AF) patients with renal function insufficiency, and to explore whether renal decline occurs in AF patients with NOAC and its impact on outcomes. In AF patients with mild renal insuf...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-11, Vol.98 (48), p.e18205-e18205
Main Authors: Gui, Yi-yue, Zou, Song, Yang, Wen-long, Gong, Shen-zhen, Cen, Zhi-fu, Xie, Zhong-hui, Cui, Kai-jun
Format: Article
Language:English
Subjects:
Anticoagulants - classification
Anticoagulants - pharmacology
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Humans
Pharmacovigilance
Renal Insufficiency - complications
Systematic Review And Meta-Analysis
Treatment Outcome
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Summary:This meta-analysis was to investigate the efficacy and safety of new oral anticoagulant (NOAC) in atrial fibrillation (AF) patients with renal function insufficiency, and to explore whether renal decline occurs in AF patients with NOAC and its impact on outcomes. In AF patients with mild renal insufficiency, the NOAC was associated with significantly lower rates of stroke (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.67-0.91; P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000018205