The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis

Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current und...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-11, Vol.98 (48), p.e18118-e18118
Main Authors: Zhang, Binjie, Zhao, Wenli, Tu, Jinli, Wang, Xueying, Hao, Yu, Wang, Hongwu, Zhao, Ye, Mizuno, Kaito, Tseng, Yiider, Bu, Huaien
Format: Article
Language:English
Subjects:
Adult
Aged
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic Neuropathies - blood
Diabetic Neuropathies - etiology
Female
Humans
Male
Middle Aged
Peripheral Nervous System Diseases - blood
Peripheral Nervous System Diseases - etiology
Risk Factors
Systematic Review and Meta-Analysis
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - etiology
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Summary:Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current understanding of this point of view remains controversial. This study aimed to evaluate the correlation between serum 25-hydroxyl vitamin D (25 [OH] D) concentration and DPN in patients with T2DM by a meta-analysis, and to provide a reference for doctors. Relevant studies were selected from the PubMed, Cochrane Library, China National Knowledge Infrastructure, VIP databases, and Wanfang Data Knowledge Service Platform databases dating from 2000 to December 2017. A total of 75 articles related to serum 25 (OH) D and DPN were selected from 2000 to December 2017. Based on the inclusion and exclusion criteria of the literature, a quality assessment was conducted using the Newcastle-Ottawa scale, and a meta-analysis was performed by RevMan5.3 statistical software. Thirteen studies that involved a total of 2814 type 2 diabetic patients were finally included into the meta-analysis. Meta-analysis results, heterogeneity test showed that, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000018118