Crystal structures of ( E )-3-(4-hy-droxy-benzyl-idene)chroman-4-one and ( E )-3-(3-hy-droxy-benzyl-idene)-2-phenyl-chroman-4-one

The synthesis and crystal structures of ( )-3-(4-hy-droxy-benzyl-idene)chroman-4-one, C H O , , and ( )-3-(3-hy-droxy-benzyl-idene)-2-phenyl-chroman-4-one, C H O , , are reported. These compounds are of inter-est with respect to biological activity. Both structures display inter-molecular C-H⋯O and...

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Published in:Acta crystallographica. Section E, Crystallographic communications Crystallographic communications, 2019-12, Vol.75 (Pt 12), p.1907-1913
Main Authors: Suchojad, Kamil, Dołęga, Anna, Adamus-Grabicka, Angelika, Budzisz, Elżbieta, Małecka, Magdalena
Format: Article
Language:English
Subjects:
Research Communications
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Summary:The synthesis and crystal structures of ( )-3-(4-hy-droxy-benzyl-idene)chroman-4-one, C H O , , and ( )-3-(3-hy-droxy-benzyl-idene)-2-phenyl-chroman-4-one, C H O , , are reported. These compounds are of inter-est with respect to biological activity. Both structures display inter-molecular C-H⋯O and O-H⋯O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound is consolidated by π-π inter-actions. The lipophilicity (log ) was determined as it is one of the parameters qualifying compounds as potential drugs. The log value for compound is associated with a larger contribution of C⋯H inter-action in the Hirshfeld surface.
ISSN:2056-9890
2056-9890
DOI:10.1107/S2056989019015639