Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors

Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of breast and colon tumor cells. In addition, it is well known that the s...

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Bibliographic Details
Published in:Cancers 2019-10, Vol.11 (11), p.1679
Main Authors: Nieto, Celia, Vega, Milena A, Enrique, Jesús, Marcelo, Gema, Martín Del Valle, Eva M
Format: Article
Language:English
Subjects:
Breast
Breast cancer
Breast carcinoma
Cancer therapies
Colon
Cytotoxicity
Dopamine
Doxorubicin
Iron
Nanoparticles
Nanotechnology
Physicochemical properties
Polymers
Stromal cells
Tumor cells
Tumors
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Summary:Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of breast and colon tumor cells. In addition, it is well known that the size of therapeutic particles plays an essential role in their effect. As a consequence, the influence of this parameter on the cytotoxicity of polydopamine nanoparticles was studied in this work. For this purpose, polydopamine nanoparticles with three different diameters (115, 200 and 420 nm) were synthetized and characterized. Their effect on the viability of distinct sorts of human carcinomas (breast, colon, liver and lung) and stromal cells was investigated, as well as the possible mechanisms that could be responsible for such cytotoxicity. Moreover, polydopamine nanoparticles were also loaded with doxorubicin and the therapeutic action of the resulting nanosystem was analyzed. As a result, it was demonstrated that a smaller nanoparticle size is related to a more enhanced antiproliferative activity, which may be a consequence of polydopamine's affinity for iron ions. Smaller nanoparticles would be able to adsorb more lysosomal Fe and, when they are loaded with doxorubicin, a synergistic effect can be achieved.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11111679