TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons

The 43-kDa transactive response DNA-binding protein (TDP-43) is an example of an RNA-binding protein that regulates RNA metabolism at multiple levels from transcription and splicing to translation. Its role in post-transcriptional RNA processing has been a primary focus of recent research, but its r...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Gene regulatory mechanisms 2019-10, Vol.1862 (10), p.194434-194434, Article 194434
Main Authors: Morera, Andrés A., Ahmed, Nasiha S., Schwartz, Jacob C.
Format: Article
Language:English
Subjects:
Alu Elements - genetics
Alu SINE
DNA-Binding Proteins - genetics
Genome, Human - genetics
GRO-seq
Humans
Open Reading Frames - genetics
Retroelements - genetics
Retrotransposon
RNA Splicing - genetics
RNA-Binding Proteins - genetics
TARDBP
TDP-43
Transcription
Transcription Factors - genetics
Transcription, Genetic
Transcriptional Activation - genetics
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Summary:The 43-kDa transactive response DNA-binding protein (TDP-43) is an example of an RNA-binding protein that regulates RNA metabolism at multiple levels from transcription and splicing to translation. Its role in post-transcriptional RNA processing has been a primary focus of recent research, but its role in regulating transcription has been studied for only a few human genes. We characterized the effects of TDP-43 on transcription genome-wide and found that TDP-43 broadly affects transcription of protein-coding and noncoding RNA genes. Among protein-coding genes, the effects of TDP-43 were greatest for genes
ISSN:1874-9399
1876-4320
DOI:10.1016/j.bbagrm.2019.194434