Prognostic Impact of CD44 Expression in Patients With Myxofibrosarcoma

Abnormal expression of CD44 may promote cancer invasion. However, a limited number of studies have investigated the expression of CD44 in soft tissue sarcoma such as myxofibrosarcoma. We evaluated the relationship between expression of the standard form of CD44 (CD44s) and the clinical course of myx...

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Bibliographic Details
Published in:In vivo (Athens) 2019-11, Vol.33 (6), p.2095-2102
Main Authors: Tsuchie, Hiroyuki, Emori, Makoto, Miyakoshi, Naohisa, Nagasawa, Hiroyuki, Okada, Kyoji, Nanjyo, Hiroshi, Murahashi, Yasutaka, Mizushima, Emi, Shimizu, Junya, Yamashita, Toshihiko, Shimada, Yoichi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor
Cell Line, Tumor
Female
Fibrosarcoma - genetics
Fibrosarcoma - metabolism
Humans
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Immunohistochemistry
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Odds Ratio
Prognosis
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Summary:Abnormal expression of CD44 may promote cancer invasion. However, a limited number of studies have investigated the expression of CD44 in soft tissue sarcoma such as myxofibrosarcoma. We evaluated the relationship between expression of the standard form of CD44 (CD44s) and the clinical course of myxofibrosarcoma. Forty-four myxofibrosarcoma patients were retrospectively enrolled. Patient information including the proportion of CD44s-positive cells was collected, and multivariate analyses were conducted to determine the relationship between CD44s expression and clinicopathological factors. Although CD44s did not affect prognosis, multivariate analysis indicated that high expression of CD44s predicted poor event-free survival (p=0.004) and local recurrence (p=0.049). CD44s expression was not associated with the occurrence of distant metastasis but was significantly higher in those with lung metastasis (p=0.044). Increased expression of CD44s predicted poor event-free survival and local recurrence and was observed in myxofibrosarcoma patients with lung metastasis.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11709