Data enabled prediction analysis assigns folate/biopterin transporter (BT1) family to 36 hypothetical membrane proteins in Leishmania donovani

Leishmaniasis is a neglected tropical disease caused by the pathogenic protozoan Leishmania donovani and it is transmitted by an infected sand fly. Approximately 0.4 million cases of Visceral Leishmaniasis are reported across the globe every year, of which 67% is from the Indian subcontinent. The cu...

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Bibliographic Details
Published in:Bioinformation 2019-10, Vol.15 (10), p.697-708
Main Authors: Ravooru, Nithin, Paul, Ojal Sarah, Nagendra, Holenarasipur Gundurao, Sathyanarayanan, Nitish
Format: Article
Language:English
Subjects:
Drug resistance
Folic acid
Functionals
Leishmania donovani
Membrane proteins
Membranes
Parasitic diseases
Phylogeny
Proteins
Proteomes
Protozoa
Toxicity
Tropical diseases
Vector-borne diseases
Visceral leishmaniasis
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Summary:Leishmaniasis is a neglected tropical disease caused by the pathogenic protozoan Leishmania donovani and it is transmitted by an infected sand fly. Approximately 0.4 million cases of Visceral Leishmaniasis are reported across the globe every year, of which 67% is from the Indian subcontinent. The currently available drugs have not been effective owing to their high toxicity levels, inadequate specificity, drug resistance, extended treatment periods and/or prohibitive prices. For this reason, hypothetical proteins in this pathogen, which constitute about 67% of its proteome, must be distinctly characterized and studied for their potential role as drug targets for Leishmaniasis. Domain information from PFAM and functional information from GO has been used to assign putative functions to 36 hypothetical membrane proteins in this protozoan. Furthermore, as a case study, we have performed a thorough sequence level characterization of a hypothetical protein E9BPD7 from the BT1 family of membrane proteins that transports folate/biopterin. Phylogenetic analyses of E9BPD7 have revealed interesting evolutionary correlations to BT1 family and MFS superfamily, which have significant roles in a number of diseases and drug resistance pathways.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630015697