Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study

Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 39...

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Bibliographic Details
Published in:Autism research 2015-10, Vol.8 (5), p.567-574
Main Authors: Lyall, Kristen, Van de Water, Judy, Ashwood, Paul, Hertz-Picciotto, Irva
Format: Article
Language:English
Subjects:
allergy
asthma
Asthma - epidemiology
autism
Autism Spectrum Disorder - epidemiology
California - epidemiology
Case-Control Studies
Child, Preschool
Comorbidity
Female
food allergy
Humans
Hypersensitivity - epidemiology
Male
Prevalence
Risk
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Summary:Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors. Autism Res 2015, 8: 567–574. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN:1939-3792
1939-3806
DOI:10.1002/aur.1471