Population reference and healthy standard blood pressure range charts in pregnancy: findings from the Born in Bradford cohort study

Women who develop gestational hypertension are at increased risk of adverse perinatal and longer-term outcomes. Reference charts may aid early detection of raised blood pressure (BP) and in doing so reduce adverse outcome risk. We used repeated BP measurements to produce ‘reference’ (whole populatio...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.18847-18847, Article 18847
Main Authors: Santorelli, Gillian, Lawlor, Debbie A., West, Jane, Tuffnell, Derek, Farrar, Diane
Format: Article
Language:English
Subjects:
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692/700
Blood Pressure
Blood Pressure Determination
Cohort analysis
Cohort Studies
Ethnicity
Female
Gestational Age
Healthy Volunteers
Humanities and Social Sciences
Humans
Hypertension
Minority & ethnic groups
multidisciplinary
Pakistan - ethnology
Population
Pregnancy
Reference Values
Science
Science (multidisciplinary)
United Kingdom
Whites
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Summary:Women who develop gestational hypertension are at increased risk of adverse perinatal and longer-term outcomes. Reference charts may aid early detection of raised blood pressure (BP) and in doing so reduce adverse outcome risk. We used repeated BP measurements to produce ‘reference’ (whole population) and ‘standard’ (healthy pregnancies only) gestational-age-specific BP charts for all pregnant women (irrespective of ethnicity) and for White British (WB) and Pakistani (P) women. We included 9218 women recruited to the Born in Bradford study with 74,770 BPs. 19% of the whole population, 11% and 25% of WB and P women respectively were defined as healthy pregnancies. For reference and standard charts, for all women and each ethnic group, SBP/DBP at 12 and 20 weeks gestation was similar before rising at 37 weeks. DBP/SBP of reference charts for all women and for each ethnic group were higher than those of the corresponding standard charts. Compared to WB, P women had lower SBP/DBP at 12, 20 and 37 weeks gestation. To conclude; maternal population BP reference charts are higher compared to standard charts (healthy pregnancies) and are influenced by ethnicity.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-55324-2