The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer

Aim. To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods. A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results. SMC4 mRNA level was significantly upregula...

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Bibliographic Details
Published in:Disease markers 2019, Vol.2019 (2019), p.1-7
Main Authors: Zheng, Min, Huang, Du-ping, Yang, Fan, Ma, Rui-min, Wang, Yi-luan
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - genetics
Age Factors
Biomarkers
Biomarkers, Tumor - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cell division
Chromosomal Proteins, Non-Histone - genetics
Chromosomes
Deoxyribonucleic acid
Development and progression
DNA
Epidermal growth factor
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genetic aspects
Genomes
Genomics
Humans
Liver cancer
Lymphatic system
Maintenance
Medical research
Messenger RNA
Metastasis
Mitochondrial DNA
Neoplasm Staging
Patients
Progesterone
Prognosis
Proteins
Risk analysis
Risk factors
RNA, Messenger - genetics
Subgroups
Survival
Survival Analysis
Up-Regulation
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Summary:Aim. To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods. A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results. SMC4 mRNA level was significantly upregulated in breast cancer tissues (P65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (HR=3.293, 95% CI 1.257-8.625, P=0.015). In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/2183057