Thrombophilic risk factors for retinal vein occlusion

The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene va...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.18972-6, Article 18972
Main Authors: Vieira, Maria J., Campos, António, do Carmo, Anália, Arruda, Henrique, Martins, Joana, Sousa, João P.
Format: Article
Language:English
Subjects:
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692/53
Adult
Age Factors
Aged
Aged, 80 and over
Enzymes
Female
Health risk assessment
Humanities and Social Sciences
Humans
Hyperhomocysteinemia
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
multidisciplinary
Occlusion
Polymorphism, Genetic
Retina
Retinal Vein Occlusion - enzymology
Retinal Vein Occlusion - etiology
Retinal Vein Occlusion - genetics
Risk Factors
Science
Science (multidisciplinary)
Thrombophilia - complications
Thrombophilia - enzymology
Thrombophilia - genetics
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Summary:The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9 versus 59.5 ± 13.7 with ≤1 CRF, [ t (57) = −2.05, p  = 0.045, d  = 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18; p  = 0.002] by the equation: 64.8 − 10.3 × (thermolabile MTHFR) − 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-55456-5