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Thrombophilic risk factors for retinal vein occlusion
The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene va...
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| Published in: | Scientific reports 2019-12, Vol.9 (1), p.18972-6, Article 18972 |
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| creator | Vieira, Maria J. Campos, António do Carmo, Anália Arruda, Henrique Martins, Joana Sousa, João P. |
| description | The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9
versus
59.5 ± 13.7 with ≤1 CRF, [
t
(57) = −2.05,
p
= 0.045,
d
= 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18;
p
= 0.002] by the equation: 64.8 − 10.3 × (thermolabile MTHFR) − 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent. |
| doi_str_mv | 10.1038/s41598-019-55456-5 |
| format | article |
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versus
59.5 ± 13.7 with ≤1 CRF, [
t
(57) = −2.05,
p
= 0.045,
d
= 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18;
p
= 0.002] by the equation: 64.8 − 10.3 × (thermolabile MTHFR) − 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-55456-5</identifier><identifier>PMID: 31831825</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/53 ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Enzymes ; Female ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Hyperhomocysteinemia ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; multidisciplinary ; Occlusion ; Polymorphism, Genetic ; Retina ; Retinal Vein Occlusion - enzymology ; Retinal Vein Occlusion - etiology ; Retinal Vein Occlusion - genetics ; Risk Factors ; Science ; Science (multidisciplinary) ; Thrombophilia - complications ; Thrombophilia - enzymology ; Thrombophilia - genetics</subject><ispartof>Scientific reports, 2019-12, Vol.9 (1), p.18972-6, Article 18972</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-54716f2e5c46f76511032a544d424938d7cdec68bd79e39cf2d1e78b6218dd5f3</citedby><cites>FETCH-LOGICAL-c501t-54716f2e5c46f76511032a544d424938d7cdec68bd79e39cf2d1e78b6218dd5f3</cites><orcidid>0000-0002-7704-4736 ; 0000-0001-9554-3427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2325295336/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2325295336?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31831825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieira, Maria J.</creatorcontrib><creatorcontrib>Campos, António</creatorcontrib><creatorcontrib>do Carmo, Anália</creatorcontrib><creatorcontrib>Arruda, Henrique</creatorcontrib><creatorcontrib>Martins, Joana</creatorcontrib><creatorcontrib>Sousa, João P.</creatorcontrib><title>Thrombophilic risk factors for retinal vein occlusion</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9
versus
59.5 ± 13.7 with ≤1 CRF, [
t
(57) = −2.05,
p
= 0.045,
d
= 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18;
p
= 0.002] by the equation: 64.8 − 10.3 × (thermolabile MTHFR) − 5.31 × ( ≤ 1CRF). 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A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9
versus
59.5 ± 13.7 with ≤1 CRF, [
t
(57) = −2.05,
p
= 0.045,
d
= 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18;
p
= 0.002] by the equation: 64.8 − 10.3 × (thermolabile MTHFR) − 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31831825</pmid><doi>10.1038/s41598-019-55456-5</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7704-4736</orcidid><orcidid>https://orcid.org/0000-0001-9554-3427</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/53 Adult Age Factors Aged Aged, 80 and over Enzymes Female Health risk assessment Humanities and Social Sciences Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged multidisciplinary Occlusion Polymorphism, Genetic Retina Retinal Vein Occlusion - enzymology Retinal Vein Occlusion - etiology Retinal Vein Occlusion - genetics Risk Factors Science Science (multidisciplinary) Thrombophilia - complications Thrombophilia - enzymology Thrombophilia - genetics |
| title | Thrombophilic risk factors for retinal vein occlusion |
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