Simultaneous Occurrence of Sarcoidosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis in a Patient with Lung Cancer

A 71-year-old woman with abnormal pulmonary shadows and multiple enlarged thoracic lymph nodes was diagnosed with stage IIB lung adenocarcinoma, pulmonary sarcoidosis, and sarcoidosis-associated lymphadenopathy after biopsies from multiple organ sites. She also had rapidly progressive renal dysfunct...

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Bibliographic Details
Published in:Internal Medicine 2019/11/15, Vol.58(22), pp.3299-3304
Main Authors: Tsuchiya, Kazuo, Karayama, Masato, Sato, Taichi, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Sugimura, Haruhiko, Yasuda, Hideo, Suda, Takafumi
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma of Lung - complications
Aged
anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications
Antibodies, Antineutrophil Cytoplasmic - immunology
Antineutrophil cytoplasmic antibodies
Biopsy
Case Report
crescentic glomerulonephritis
Female
Glomerulonephritis
Glomerulonephritis - etiology
Hematuria
Humans
Internal medicine
Lung cancer
Lung Neoplasms - complications
Lymph nodes
Lymphadenopathy
Nephritis
Nephritis, Interstitial - etiology
Neutrophils
Peroxidase
Prednisolone
Renal function
Sarcoidosis
Sarcoidosis - complications
Thorax
Vasculitis
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Description
Summary:A 71-year-old woman with abnormal pulmonary shadows and multiple enlarged thoracic lymph nodes was diagnosed with stage IIB lung adenocarcinoma, pulmonary sarcoidosis, and sarcoidosis-associated lymphadenopathy after biopsies from multiple organ sites. She also had rapidly progressive renal dysfunction, microhematuria, and high myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) concentrations. A renal biopsy revealed granulomatous tubulointerstitial nephritis and necrotizing glomerulonephritis with crescent formation. She was diagnosed with nephritis caused by both sarcoidosis and ANCA-associated vasculitis. Oral prednisolone was administered to treat her nephritis, resulting in improvement in both her renal dysfunction and her sarcoidosis-associated lymphadenopathy.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3004-19