Limited Intrahost Diversity and Background Evolution Accompany 40 Years of Canine Parvovirus Host Adaptation and Spread

Canine parvovirus (CPV) is a highly successful pathogen that has sustained pandemic circulation in dogs for more than 40 years. Here, integrating full-genome and deep-sequencing analyses, structural information, and experimentation, we describe the macro- and microscale features that accompany CPV&#...

Full description

Saved in:
Bibliographic Details
Published in:Journal of virology 2019-12, Vol.94 (1)
Main Authors: Voorhees, Ian E H, Lee, Hyunwook, Allison, Andrew B, Lopez-Astacio, Robert, Goodman, Laura B, Oyesola, Oyebola O, Omobowale, Olutayo, Fagbohun, Olusegun, Dubovi, Edward J, Hafenstein, Susan L, Holmes, Edward C, Parrish, Colin R
Format: Article
Language:English
Subjects:
Adaptation, Physiological - genetics
Animals
Biological Evolution
Capsid Proteins - classification
Capsid Proteins - genetics
Capsid Proteins - metabolism
DNA, Viral - genetics
DNA, Viral - metabolism
Dog Diseases - epidemiology
Dog Diseases - transmission
Dog Diseases - virology
Dogs
Foxes - virology
Genome and Regulation of Viral Gene Expression
Genome, Viral
Host Specificity - genetics
Models, Molecular
Mutation
Parvoviridae Infections - epidemiology
Parvoviridae Infections - transmission
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Parvovirus, Canine - classification
Parvovirus, Canine - genetics
Parvovirus, Canine - pathogenicity
Phylogeny
Protein Conformation
Raccoon Dogs - virology
Raccoons - virology
Viral Nonstructural Proteins - classification
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
Whole Genome Sequencing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Canine parvovirus (CPV) is a highly successful pathogen that has sustained pandemic circulation in dogs for more than 40 years. Here, integrating full-genome and deep-sequencing analyses, structural information, and experimentation, we describe the macro- and microscale features that accompany CPV's evolutionary success. Despite 40 years of viral evolution, all CPV variants are more than ∼99% identical in nucleotide sequence, with only a limited number (
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01162-19