Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, C...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematologic oncology 2019-08, Vol.8 (3), p.IJH22-IJH22
Main Authors: Mikhael, Neveen L, Seif H Gendi, Myriam Abo, Hassab, Hoda, Megahed, Elshaymaa A
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Angiogenesis
Antibodies
Biomarkers
Bone marrow
Cell adhesion & migration
Chemokines
Chemotherapy
CNS infiltration
Cytokines
Disease
Flow cytometry
Lasers
Leukemia
Metastasis
Nervous system
Patients
Pediatrics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.
ISSN:2045-1393
2045-1407
DOI:10.2217/ijh-2019-0008