Serum concentration of angiogenic (CXCL1, CXCL12) and angiostasis (CXCL9, CXCL10) CXC chemokines are differentially altered in normal and gestational diabetes mellitus associated pregnancies

Background The present study was aimed and designed to determine the serum levels of CXCL1 and CXCL12 as angiogenesis along with CXCL9 and CXCL10 as angiostasis, chemokines in, Gestational diabetes mellitus mothers (GDMM) and normal pregnancy mothers (NPM) and neonates who delivered by them. Methods...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2019-12, Vol.18 (2), p.371-378
Main Authors: Darakhshan, Shokoofeh, Fatehi, Abbas, Hassanshahi, Gholamhossein, Mahmoodi, Soodabeh, Hashemi, Monireh Seyed, Karimabad, Mojgan Noroozi
Format: Article
Language:English
Subjects:
Chemokines
Development and progression
Diabetes
Diabetes mellitus
Diagnosis
Endocrinology
Enzyme-linked immunosorbent assay
Gestational diabetes
Health aspects
Health risk assessment
Measurement
Medicine
Medicine & Public Health
Metabolic Diseases
Neovascularization
Newborn infants
Pregnancy
Research Article
Type 2 diabetes
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Summary:Background The present study was aimed and designed to determine the serum levels of CXCL1 and CXCL12 as angiogenesis along with CXCL9 and CXCL10 as angiostasis, chemokines in, Gestational diabetes mellitus mothers (GDMM) and normal pregnancy mothers (NPM) and neonates who delivered by them. Methods We have recruited 63 pregnant GDMM and 63 normal pregnant mothers at the third trimester of pregnancy to this cross-sectional study. Cord blood specimens were obtained from neonates who were delivered from GDMM and NPM. The serum and cord blood levels of chemokines were measured by ELISA in studied groups. Data were analyzed by chi-square and student’s t test between two groups. The P- values less than 0.05 were considered significant. Results Our results revealed that the serum levels of CXCL1, CXCL9 and CXCL12 were increased in GDMM, while no alteration was found in the serum levels of CXCL10 when compared to NPM. We have observed that in neonates the serum levels of angiogeneic chemokines followed an inverse fashion when compared to angiostasis chemokines. Interestingly, CXCL1 and CXCL12 were both increased in neonates who were delivered by GDMM, while, CXCL9 and CXCL10 were decreased in neonates delivered by GDMM.
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-019-00421-2