Cupredoxins--a study of how proteins may evolve to use metals for bioenergetic processes

Cupredoxins are small proteins that contain type I copper centers, which are ubiquitous in nature. They function as electron transfer shuttles between proteins. This review of the structure and properties of native cupredoxins, and those modified by site-directed mutagenesis, illustrates how these p...

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Published in:Metallomics 2011-02, Vol.3 (2), p.140-151
Main Authors: Choi, Moonsung, Davidson, Victor L
Format: Article
Language:English
Subjects:
Azurin - chemistry
Azurin - metabolism
Binding Sites
Copper - chemistry
Copper - metabolism
Models, Molecular
Plastocyanin - chemistry
Plastocyanin - metabolism
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description Cupredoxins are small proteins that contain type I copper centers, which are ubiquitous in nature. They function as electron transfer shuttles between proteins. This review of the structure and properties of native cupredoxins, and those modified by site-directed mutagenesis, illustrates how these proteins may have evolved to specifically bind copper, develop recognition sites for specific redox partners, tune redox potential for a particular function, and allow for efficient electron transfer through the protein matrix. This is relevant to the general understanding of the roles of metals in energy metabolism, respiration and photosynthesis.
doi_str_mv 10.1039/c0mt00061b
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source Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list)
subjects Azurin - chemistry
Azurin - metabolism
Binding Sites
Copper - chemistry
Copper - metabolism
Models, Molecular
Plastocyanin - chemistry
Plastocyanin - metabolism
title Cupredoxins--a study of how proteins may evolve to use metals for bioenergetic processes
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