Sequence Variation Associated with SLC12A5 Gene Expression Is Linked to Brain Structure and Function in Healthy Adults

Abstract A single-nucleotide polymorphism in the promoter region of the Matrix Metalloproteinase-9 (MMP9) gene, rs3918242, has been shown to affect MMP9 expression in macrophages and was associated with schizophrenia by two independent groups. However, rs3918242's effects on MMP9 expression wer...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2019-12, Vol.29 (11), p.4654-4661
Main Authors: Gregory, Michael D, Kippenhan, J Shane, Callicott, Joseph H, Rubinstein, Daniel Y, Mattay, Venkata S, Coppola, Richard, Berman, Karen F
Format: Article
Language:English
Subjects:
Adult
Brain - anatomy & histology
Brain - physiology
Brain Mapping
Female
Gene Expression
Genotype
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Memory, Short-Term - physiology
Original
Polymorphism, Single Nucleotide
Symporters - genetics
Symporters - physiology
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Summary:Abstract A single-nucleotide polymorphism in the promoter region of the Matrix Metalloproteinase-9 (MMP9) gene, rs3918242, has been shown to affect MMP9 expression in macrophages and was associated with schizophrenia by two independent groups. However, rs3918242's effects on MMP9 expression were not replicable in cell lines or brain tissue. Additionally, publically available data indicate that rs3918242 genotype is related not to MMP9 expression, but rather to expression of SLC12A5, a nearby gene coding for a K+/Cl- cotransporter, whose expression has also been related to schizophrenia. Here, we studied brain structure and function in healthy participants stratified by rs3918242 genotype using structural MRI (N = 298), functional MRI during an N-back working memory task (N = 554), and magnetoencephalography (MEG) during the same task (N = 190). We found rs3918242 was associated with gray matter volume (GMV) in the insula and dorsolateral prefrontal cortex bilaterally, closely replicated in discovery and replication samples; and with inferior parietal lobule (IPL) GMV when the samples were meta-analytically combined. Additionally, using both fMRI and MEG, rs3918242 was associated with right IPL working memory-related activation, replicated in two cohorts and across imaging modalities. These convergent results provide further impetus for examinations of the relationship of SLC12A5 with brain structure and function in neuropsychiatric disease.
ISSN:1047-3211
1460-2199
1460-2199
DOI:10.1093/cercor/bhy344