Can preoperative neutrophil to lymphocyte, lymphocyte to monocyte, or platelet to lymphocyte ratios differentiate glioblastoma from brain metastasis?

This retrospective analysis of patients aims to show the blood levels of preoperative inflammatory markers in patients with glioblastoma and brain metastasis and to provide the diagnostic accuracy of the neutrophil-lymphocyte (NLR), lymphocyte-monocyte (LMR), and platelet-lymphocyte (PLR) ratios bet...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-12, Vol.98 (50), p.e18306-e18306
Main Authors: Baran, Oguz, Kemerdere, Rahsan, Korkmaz, Taha Sukru, Kayhan, Ahmet, Tanriverdi, Taner
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - blood
Blood Platelets - pathology
Brain Neoplasms - diagnosis
Brain Neoplasms - secondary
Diagnosis, Differential
Female
Follow-Up Studies
Glioblastoma - diagnosis
Glioblastoma - surgery
Humans
Lymphocyte Count
Lymphocytes - pathology
Male
Middle Aged
Monocytes - pathology
Neoplasm Metastasis
Neurosurgical Procedures
Neutrophils - pathology
Observational Study
Platelet Count
Preoperative Period
Retrospective Studies
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Summary:This retrospective analysis of patients aims to show the blood levels of preoperative inflammatory markers in patients with glioblastoma and brain metastasis and to provide the diagnostic accuracy of the neutrophil-lymphocyte (NLR), lymphocyte-monocyte (LMR), and platelet-lymphocyte (PLR) ratios between the 2 groups of patients.The retrospective reviews of the neutrophil, lymphocyte, monocyte, and platelet counts were analyzed in 80 patients with newly diagnosed glioblastoma and 70 patients with brain metastasis. The NLR, LMR, and PLR were calculated in each group. The differences in all the parameters were compared between the 2 groups.Although the neutrophil, monocyte, and platelet counts were higher and the lymphocyte count was lower in patients with metastasis, the difference was not significant. A significantly higher PLR (P = .004) and a lower LMR (P = .01) were found in patients with brain metastasis. Although both PLR and LMR had diagnostic accuracy in differentiating glioblastoma from brain metastasis, LMR showed the highest diagnostic accuracy. NLR showed no diagnostic accuracy.Systemic inflammation is more severe in glioblastoma than in brain metastasis, and LMR is more sensitive and/or specific than PLR in differentiating glioblastoma from brain metastasis. Therefore, LMR (less likely PLR) can be used as an index for differentiating between glioblastoma and brain metastasis before surgery.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000018306