Smoking and risk of incident end-stage kidney disease in general population: A Nationwide Population-based Cohort Study from Korea

We analyzed data from the Korean National Health Insurance Service (NHIS) to investigate whether smoking increases the risk of end-stage kidney disease (ESKD). This retrospective nationwide population-based cohort study included the data of 23,232,091 participants who underwent at least one health e...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.19511-8, Article 19511
Main Authors: Choi, Hong Sang, Han, Kyung-Do, Oh, Tae Ryom, Kim, Chang Seong, Bae, Eun Hui, Ma, Seong Kwon, Kim, Soo Wan
Format: Article
Language:English
Subjects:
692/4022/1585/104/1586
692/4022/1950
Adult
Aged
Cigarettes
Cohort analysis
Cohort Studies
End-stage renal disease
Female
Humanities and Social Sciences
Humans
Incidence
Kidney diseases
Kidney Failure, Chronic - epidemiology
Kidneys
Korea - epidemiology
Male
Middle Aged
multidisciplinary
Population
Population studies
Population-based studies
Proportional Hazards Models
Science
Science (multidisciplinary)
Smoking
Smoking - adverse effects
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Summary:We analyzed data from the Korean National Health Insurance Service (NHIS) to investigate whether smoking increases the risk of end-stage kidney disease (ESKD). This retrospective nationwide population-based cohort study included the data of 23,232,091 participants who underwent at least one health examination between 2009 and 2012. Smoking status was recorded at baseline. The incidence of ESKD was identified via ICD-10 codes and special medical aid codes from the Korean National Health Insurance Service database till December 2016. A Cox proportional-hazards model with multivariable adjustment was used to evaluate the association between smoking and ESKD incidence. Overall, 24.6% of participants were current smokers; 13.5% and 61.9%, were ex- and non-smokers, respectively. Overall, 45,143 cases of ESKD developed during the follow-up period. Current smokers (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.35–1.43) and ex-smokers (HR, 1.09; 95% CI, 1.06–1.12) demonstrated a significant increase in the adjusted risk of ESKD compared to non-smokers. The risk of ESKD was directly proportional to the smoking duration, number of cigarettes smoked daily, and pack-years. In conclusion, smoking is associated with a greater risk of ESKD in the general Korean population; the risk increases with an increase in the smoking duration, number of cigarettes smoked daily, and pack-years.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-56113-7