Intraoperative quantitative functional brain mapping using an RGB camera

Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular, new biomarkers of brain functionality with improved sensitivity and spec...

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Bibliographic Details
Published in:Neurophotonics (Print) 2019-10, Vol.6 (4), p.045015-045015
Main Authors: Caredda, Charly, Mahieu-Williame, Laurent, Sablong, Raphaël, Sdika, Michaël, Alston, Laure, Guyotat, Jacques, Montcel, Bruno
Format: Article
Language:English
Subjects:
Bioengineering
Biomarkers
Blood
Blood vessels
Brain cancer
Brain mapping
Cameras
Electrical stimulation of the brain
ESB
Hemodynamics
Hemoglobin
Imaging
Life Sciences
Light
Localization
Magnetic resonance imaging
Monte Carlo simulation
Neuroimaging
Neurosurgery
Optical properties
Patients
Research Papers
Surgery
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Summary:Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular, new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the computation of hemodynamics-based functional brain maps using an RGB camera and a white light source. We measure the quantitative oxy and deoxyhemoglobin concentration changes in the human brain cortex with the modified Beer–Lambert law and Monte Carlo simulations. A functional model has been implemented to evaluate the functional brain areas following neuronal activation by physiological stimuli. The results show a good correlation between the computed quantitative functional maps and the brain areas localized by electrical brain stimulation (EBS). We demonstrate that an RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in a robust way the functional areas during neurosurgery and serve as a tool of choice to complement EBS.
ISSN:2329-423X
2329-4248
DOI:10.1117/1.NPh.6.4.045015